1586016-83-2Relevant academic research and scientific papers
Solvent-free, mild, facile, and rapid one-pot three-component synthesis of some novel imidazo[2,1-b]naphtho[1,2-e][1,3] thiazin-10-ones using p-TSA
Ghanbari, Mohammad M.,Jamali, Marzieh,Batta, Gyula
, p. 394 - 398 (2014/06/10)
Novel [2,1-b]naphtho[1,2-e][1,3]thiazin-10-ones were synthesized in 63-89% yield via a three-component reaction of an aromatic aldehyde, β-naphthol, and thiohydantoin in the presence of 10 mol% p-toluene sulfonic acid under solvent-free conditions. This is the first protocol to be reported for the synthesis of the title compounds. The significant features of the present protocol are simplicity, high yields, eco-friendliness, and convenient purification that does not require chromatography.
