158606-71-4Relevant academic research and scientific papers
3-Substituted indolizine-1-carbonitrile derivatives as phosphatase inhibitors
Weide, Timo,Arve, Lars,Prinz, Heino,Waldmann, Herbert,Kessler, Horst
, p. 59 - 63 (2006)
In the course of studies directed toward the discovery of novel scaffolds for medicinal application, we synthesized a series of 3-substituted indolizine-1-carbonitrile derivatives. Some of them displayed activity against MPtpA/MPtpB phosphatases which are involved in infectious diseases. We report here the solid-phase synthesis and antiphosphatase activity of a series of indolizines.
ARYL AND HETEROARYLMETHOXYPHENYL INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS
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, (2008/06/13)
The present invention relates to a compound of the formula or a pharmaceutically acceptable salt thereof wherein W is selected from optionally substituted pyridyl, naphthyl, and quinolyl; which inhibits lipoxygenase enzyme activity and leukotriene biosynt
