158608-95-8Relevant academic research and scientific papers
Nickel-Catalyzed 1,2-Diarylation of Simple Alkenyl Amides
Derosa, Joseph,Kleinmans, Roman,Tran, Van T.,Karunananda, Malkanthi K.,Wisniewski, Steven R.,Eastgate, Martin D.,Engle, Keary M.
supporting information, p. 17878 - 17883 (2019/01/04)
A nickel-catalyzed conjunctive cross-coupling of simple alkenyl amides with aryl iodides and aryl boronic esters is reported. The reaction is enabled by an electron-deficient olefin (EDO) ligand, dimethyl fumarate, and delivers the desired 1,2-diarylated products with excellent regiocontrol. Under optimized conditions, a wide range of amides derived from 3-butenoic acid, 4-pentenoic acid, and allyl amine are compatible substrates. This method represents the first example of regiocontrolled 1,2-diarylation directed by a native amide functional group. Computational analysis sheds light on the potential substrate binding mode and the role of the EDO ligand in the reductive elimination step.
Synthesis and evaluation of antitumor activity of arylamides and cyclohexylamides of isomeric 3-chloro-4-(2-chloroethylthio)butanoic- and 4-chloro-3-(2-chloroethylthio)butanoic acids
Vektariene, Ausra,Palaima, Algirdas,Simkeviciene, Vitalija
, p. 217 - 222 (2007/10/03)
In the hope to find antitumor candidates among di-(2-chloroethyl)sulfides it was found that only 3-chloro-4-(2-chloroethylthio)butanoic (3-chloro) and 4-chloro-3-(2-chloroethylthio)butanoic (4-chloro) acids possess definite alkylating ability which is sug
Synthesis and some transformations of N-cyclohexyl-3(4)-chloro-4(3)-methylthiobutyramides
Pociute, N. B. K.,Jeleniauskaite, S. F.,Karpavicius, K. K.
, p. 199 - 200 (2007/10/02)
Addition of methylsulfenyl chloride to N-cyclohexyl-3-butenamide yields N-cyclohexyl-4-chloro-3-methylthiobutyramide.Isomerization, oxidation of the latter, and β-elimination were studied.
