158610-02-7

Basic information

• Product Name: 2,6-bis(3,4-diacetoxybenzylidene)cyclohexanone
• Synonyms: 2,6-bis(3,4-diacetoxybenzylidene)cyclohexanone
• CAS NO: 158610-02-7
• Molecular Weight: 506.509
• Mol File: 158610-02-7.mol

Chemical Properties

• CAS DataBase Reference: 2,6-bis(3,4-diacetoxybenzylidene)cyclohexanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-bis(3,4-diacetoxybenzylidene)cyclohexanone(158610-02-7)
• EPA Substance Registry System: 2,6-bis(3,4-diacetoxybenzylidene)cyclohexanone(158610-02-7)

Safety Data

• Hazardous Substances Data: 158610-02-7(Hazardous Substances Data)

Upstream product

• 142381-66-6 2,6-bis(3,4-dihydroxybenzylidene)cyclohexanone 
• 108-24-7 acetic anhydride 
• 108-94-1 cyclohexanone 
• 139-85-5 3,4-dihydroxybenzaldehyde 

Relevant articles and documents

Synthesis and evaluation of DPPH and anti-inflammatory activities of 2,6-bisbenzylidenecyclohexanone and pyrazoline derivatives

A series of thirty three 2,6-bisbenzylidenecyclohexanone and pyrazoline derivatives were synthesized and evaluated for inhibitory activities on IFN-γ/LPS-activated RAW 264.7 cells and DPPH radical scavenging activity. Compounds 8, 9, and 11a demonstrated significant NO inhibitory activity as compared to L-NAME and curcumin with IC50 values of 6.68 ± 0.16, 6.09 ± 0.46, and 6.84 ± 0.12 μM, respectively. Apparently the suppression upon NO secretion was not due to cell death since the active compounds did not reduce the cell viability in close proximity to the IC 50 of NO inhibition. Overall, incorporation of pyrazoline ring as part of the linker chain improved cell viability compared to the 2,6-bisbenzylidenecyclohexanone derivatives. Meanwhile, compound 11 (IC 50 = 13.27 ± 1.78 μM) bearing ortho hydroxyls on the aromatic rings recorded the highest radical scavenging activity as compared with quercetin (IC50 = 21.46 ± 0.85 μM). Springer Science+Business Media, LLC 2010.