15862-42-7

Usage

Uses

Used in Pharmaceutical Research:
5-Bromo-2-hydrazino-3-nitropyridine is used as a building block for the synthesis of biologically active molecules, contributing to the development of new pharmaceuticals due to its versatile chemical structure and potential pharmacological properties.
Used in Organic Synthesis:
As a reagent, 5-Bromo-2-hydrazino-3-nitropyridine is used in the preparation of heterocyclic compounds, which are important in various chemical and pharmaceutical applications.
Used in Antitumor Applications:
5-Bromo-2-hydrazino-3-nitropyridine is studied for its potential antitumor activity, suggesting its use as a precursor in the development of cancer therapeutics.
Used in Antibacterial Applications:
5-Bromo-2-hydrazino-3-nitropyridine is also being investigated for its antibacterial properties, indicating its potential use in the creation of new antibiotics to combat resistant bacterial strains.
Used as a Precursor for Pharmaceutical Intermediates:
Due to its chemical properties, 5-Bromo-2-hydrazino-3-nitropyridine serves as a precursor in the synthesis of pharmaceutical intermediates, which are essential in the production of various medications.

InChI:InChI=1/C5H5BrN4O2/c6-3-1-4(10(11)12)5(9-7)8-2-3/h1-2H,7H2,(H,8,9)

Upstream product

• 67443-38-3 5-bromo-2-chloro-3-nitropyridine 

Downstream Products

• 15862-30-3 3-bromo-5-nitro-pyridine 

Relevant academic research and scientific papers

1,2,4-triazolo[4,3-a] pyridine derivative as well as preparation method and application thereof

The invention discloses a 1,2,4-triazolo[4,3-a] pyridine derivative as well as a preparation method and application thereof, and belongs to the field of chemical medicines. The invention provides a compound shown as a formula I or pharmaceutically acceptable salt thereof. The invention also provides a preparation method and application of the compound. Biological experiments show that the compoundhas an obvious inhibition effect on NO releasing of cells, can obviously improve lesions caused by autoimmune hepatitis, and provides a new choice for development and application of anti-liver injury, especially anti-autoimmune disease drugs.

Reactions of 3-R-5-nitropyridines with nucleophiles: Nucleophilic substitution vs conjugate addition

A number of 3-R-5-nitropyridines were synthesized and their reactions with various types of nucleophiles were investigated. The reaction outcome depends on the nature of a nucleophile: in case of anionic O-, N- and S-nucleophiles the previously unreported substitution of non-activated nitro group occurred while carbon nucleophiles underwent dearomatization of the pyridine ring with the formation of products of 1,2- and 1,4-addition.

Synthesis and biological evaluation of (1,2,4)triazole[4,3-a]pyridine derivatives as potential therapeutic agents for concanavalin A-induced hepatitis

A series of (1,2,4)triazole[4,3-a]pyridine (TZP) derivatives have been designed and synthesized. Compound 8d was identified as having the most potent inhibitory activity on NO release in response to lipopolysaccharide (LPS) stimulation and inhibition of the migration induced by MCP-1 protein on RAW264.7 macrophages. Based on the screening data, an immunofluorescence assay and a real-time qPCR assay were conducted, indicating that compound 8d suppressed NF-κB p65 translocation and expression of inflammatory genes by concanavalin A (Con A)-induced RAW264.7 macrophages. More importantly, 8d also exhibited potent efficacy, alleviating Con A-induced hepatitis by downregulating the levels of plasma alanine transaminase (ALT), aspartate transaminase (AST) and inflammatory infiltration in a mouse autoimmune hepatitis (AIH) model. In addition, the flow cytometry (FCM) data showed that compound 8d inhibited the accumulation of MDSCs in the liver of Con A-induced mice. These findings raise the possibility that compound 8d might serve as a potential agent for the treatment of AIH.