15862-42-7

Basic information

• Product Name: 5-Bromo-2-hydrazino-3-nitropyridine
• Synonyms: 5-Bromo-2-hydrazino-3-nitropyridine;(5-BroMo-3-nitro-pyridin-2-yl)-hydrazine
• CAS NO: 15862-42-7
• Molecular Formula: C₅H₅BrN₄O₂
• Molecular Weight: 233.03
• Product Categories: blocks;Carboxes;Pyridines;Pyridine
• Mol File: 15862-42-7.mol
• Article Data: 3

Chemical Properties

• Melting Point: 138 °C(Solv: methanol (67-56-1))
• Boiling Point: 342.2 °C at 760 mmHg
• Flash Point: 160.8 °C
• Appearance: /
• Density: 1.986 g/cm³
• Vapor Pressure: 7.64E-05mmHg at 25°C
• Refractive Index: 1.735
• Storage Temp.: 2-8°C
• PKA: 3.96±0.70(Predicted)
• CAS DataBase Reference: 5-Bromo-2-hydrazino-3-nitropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-2-hydrazino-3-nitropyridine(15862-42-7)
• EPA Substance Registry System: 5-Bromo-2-hydrazino-3-nitropyridine(15862-42-7)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 15862-42-7(Hazardous Substances Data)

Usage

General Description

5-Bromo-2-hydrazino-3-nitropyridine is a chemical compound with the formula C5H4BrN5O2. It is a yellow crystalline solid that is commonly used in organic synthesis and pharmaceutical research. 5-Bromo-2-hydrazino-3-nitropyridine is a nitro-substituted pyridine derivative and it is often utilized as a building block in the synthesis of various biologically active molecules. 5-Bromo-2-hydrazino-3-nitropyridine has been studied for its potential pharmacological properties, including antitumor and antibacterial activities. It is also a useful reagent in the preparation of heterocyclic compounds and can serve as a precursor for pharmaceutical intermediates.

InChI:InChI=1/C5H5BrN4O2/c6-3-1-4(10(11)12)5(9-7)8-2-3/h1-2H,7H2,(H,8,9)

Upstream product

• 67443-38-3 5-bromo-2-chloro-3-nitropyridine 

Relevant articles and documents

1,2,4-triazolo[4,3-a] pyridine derivative as well as preparation method and application thereof

The invention discloses a 1,2,4-triazolo[4,3-a] pyridine derivative as well as a preparation method and application thereof, and belongs to the field of chemical medicines. The invention provides a compound shown as a formula I or pharmaceutically acceptable salt thereof. The invention also provides a preparation method and application of the compound. Biological experiments show that the compoundhas an obvious inhibition effect on NO releasing of cells, can obviously improve lesions caused by autoimmune hepatitis, and provides a new choice for development and application of anti-liver injury, especially anti-autoimmune disease drugs.

Synthesis and biological evaluation of (1,2,4)triazole[4,3-a]pyridine derivatives as potential therapeutic agents for concanavalin A-induced hepatitis

A series of (1,2,4)triazole[4,3-a]pyridine (TZP) derivatives have been designed and synthesized. Compound 8d was identified as having the most potent inhibitory activity on NO release in response to lipopolysaccharide (LPS) stimulation and inhibition of the migration induced by MCP-1 protein on RAW264.7 macrophages. Based on the screening data, an immunofluorescence assay and a real-time qPCR assay were conducted, indicating that compound 8d suppressed NF-κB p65 translocation and expression of inflammatory genes by concanavalin A (Con A)-induced RAW264.7 macrophages. More importantly, 8d also exhibited potent efficacy, alleviating Con A-induced hepatitis by downregulating the levels of plasma alanine transaminase (ALT), aspartate transaminase (AST) and inflammatory infiltration in a mouse autoimmune hepatitis (AIH) model. In addition, the flow cytometry (FCM) data showed that compound 8d inhibited the accumulation of MDSCs in the liver of Con A-induced mice. These findings raise the possibility that compound 8d might serve as a potential agent for the treatment of AIH.