158654-89-8

Basic information

• Product Name: tert-Butyl 4-(1H-imidazol-1-yl)piperidine-1-carboxylate
• Synonyms: tert-Butyl 4-(1H-imidazol-1-yl)piperidine-1-carboxylate
• CAS NO: 158654-89-8
• Molecular Formula: C₁₃H₂₁N₃O₂
• Molecular Weight: 251.32
• Mol File: 158654-89-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 405.0±38.0 °C(Predicted)
• Appearance: /
• Density: 1.15±0.1 g/cm3(Predicted)
• PKA: 6.85±0.10(Predicted)
• CAS DataBase Reference: tert-Butyl 4-(1H-imidazol-1-yl)piperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl 4-(1H-imidazol-1-yl)piperidine-1-carboxylate(158654-89-8)
• EPA Substance Registry System: tert-Butyl 4-(1H-imidazol-1-yl)piperidine-1-carboxylate(158654-89-8)

Safety Data

• Hazardous Substances Data: 158654-89-8(Hazardous Substances Data)

Upstream product

• 288-32-4 1H-imidazole 
• 141699-59-4 1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate 

Downstream Products

• 147081-85-4 4-(1H-imidazol-1-yl)-piperidine 

Relevant articles and documents

Certain Nitrogen Containing Bicyclic Chemical Entities for Treating Viral Infections

Provided are certain chemical entities, pharmaceutical compositions, and methods of treatment of a member of the flaviviradae family of viruses such as hepacivirus (Hepatitis C or HCV).

Novel farnesyl protein transferase inhibitors as antitumor agents

Disclosed are novel tricyclic compounds represented by the formula (1.0): and a pharmaceutically acceptable salt or solvate thereof. The compounds are useful for inhibiting farnesyl protein transferase. Also disclosed are pharmaceutical compositions comprising compounds of formula 1.0. Also disclosed are methods of treating cancer using the compounds of formula 1.0.

Farnesyl protein transferase inhibitors

Disclosed are compounds of the formula: wherein R8represents a cyclic moiety to which is bound an imodazolylalkyl group; R9represents a carbamate, urea, amide or sulfonamide group; and the remaining substituents are as defined herein. Also disclosed is a method of treating cancer and a method of inhibiting farnesyl protein transferase using the disclosed compounds.