158663-69-5

Basic information

• Product Name: (S)-Piperazine-2-carboxylic acid dihydrochloride
• Synonyms: (S)-PIPERAZINE-2-CARBOXYLIC ACID 2HCL;(S)-(-)-PIPERAZINE-2-CARBOXYLIC ACID DIHYDROCHLORIDE;(S)-PIPERAZINE-2-CARBOXYLIC ACID DIHYDROCHLORIDE;(S)-(-)-2-PIPERAZINECARBOXYLIC ACID DIHYDROCHLORIDE;(2S)-2-Piperazinecarboxylic acid dihydrochloride;2-PIPERAZINECARBOXYLIC ACID, DIHYDROCHLORIDE, (2S)-;2-PIPERAZINECARBOXYLIC ACID, (S)-, DIHYDROCHLORIDE;(S)-(-)-PIPERAZINE-2-CARBOXYLIC ACID DIHCL
• CAS NO: 158663-69-5
• Molecular Formula: C5H12Cl2N2O2
• Molecular Weight: 203.07
• Product Categories: Amino acids, non natural;Chiral Compounds;pharmacetical;Piperazines;Amino Acids;I - ZPeptide Synthesis;Modified Amino Acids;Others;Unnatural Amino Acid Derivatives;amino acids;NULL
• Mol File: 158663-69-5.mol
• Article Data: 0

Chemical Properties

• Melting Point: 280°C
• Boiling Point: 313.6 °C at 760 mmHg
• Flash Point: 143.5 °C
• Appearance: /
• Vapor Pressure: 0.000107mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• Sensitive: Hygroscopic
• BRN: 7312035
• CAS DataBase Reference: (S)-Piperazine-2-carboxylic acid dihydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-Piperazine-2-carboxylic acid dihydrochloride(158663-69-5)
• EPA Substance Registry System: (S)-Piperazine-2-carboxylic acid dihydrochloride(158663-69-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• F: 3-10
• Hazardous Substances Data: 158663-69-5(Hazardous Substances Data)

Usage

Description

(S)-Piperazine-2-carboxylic acid dihydrochloride is an organic compound that is a derivative of piperazine, featuring a carboxylic acid group at the 2-position. It is a chiral molecule, with the (S)-configuration indicating the spatial arrangement of its atoms. (S)-Piperazine-2-carboxylic acid dihydrochloride is often utilized in the synthesis of various pharmaceuticals and biologically active molecules due to its unique structural properties.

Uses

Used in Pharmaceutical Industry:
(S)-Piperazine-2-carboxylic acid dihydrochloride is used as a key intermediate for the synthesis of various pharmaceuticals and biologically active compounds. Its application is primarily due to its ability to be incorporated into complex molecular structures, contributing to the development of new drugs with specific therapeutic properties.
Used in Enzymatic Synthesis:
(S)-Piperazine-2-carboxylic acid dihydrochloride is used as a substrate in the preparation of optically pure (S)-piperazine-2-carboxylic acid, (R)-piperazine-2-carboxylic acid, and (S)-piperidine-2-carboxylic acid through kinetic resolution. This process involves the use of stereoselective amidases in whole bacterial cells, which selectively convert one enantiomer of the racemic carboxamides into the desired product, while the other enantiomer remains unreacted. This method is valuable for obtaining enantiomerically pure compounds, which are essential in the pharmaceutical industry to ensure the desired biological activity and minimize potential side effects.

InChI:InChI=1/C5H10N2O2.2ClH/c8-5(9)4-3-6-1-2-7-4;;/h4,6-7H,1-3H2,(H,8,9);2*1H/t4-;;/m0../s1