158663-82-2Relevant academic research and scientific papers
Stereocontrol between remote atom centers in acyclic substrates. Anti addition of hydride to 1,5-, 1,6-, and 1,7-hydroxy ketones
Zhang, Han-Cheng,Harris, Bruce D.,Costanzo, Michael J.,Lawson, Edward C.,Maryanoff, Cynthia A.,Maryanoff, Bruce E.
, p. 7964 - 7981 (2007/10/03)
For conformationally unconstrained, acyclic organic compounds, the control of stereogenic centers at remote positions of a chain, that is, at a distance of four or more atom centers, remains a challenging problem in asymmetric synthesis. We report on our
Remote acyclic diastereocontol involving a bicyclic metal chelate. High 1,5 asymmetric induction in the hydride reduction of δ-hydroxy ketones
Zhang, Han-Cheng,Costanzo, Michael J.,Maryanoff, Bruce E.
, p. 4891 - 4894 (2007/10/02)
A variety of reducing agents was explored to effect stereoselective reduction of acyclic δ-hydroxy ketone 3a; R-Alpine-Hydride provided high anti stereoselectivity (anti:syn = 7:1). Reduction of 3b in CH2Cl2 with R-Alpine-Hydride or
