158666-65-0Relevant academic research and scientific papers
Annulation Reactions of 3-Aminoisoquinolin-1(2H)-one. Synthesis of Pyrimidoisoquinolines, Pyridoisoquinolines and Pyrroloisoquinolines
Deady, Leslie W.,Quazi, Nurul H.
, p. 793 - 796 (2007/10/02)
Reactions of the title compound with the malonic acid derivatives diethyl ethoxymethylenemalonate (EMME), ethyl ethoxymethylenecyanoacetate (EMCA) and ethoxymethylenemalononitrile (EMMN) are reported.Condensations occur at the amino group or C-4, depending on conditions and the former intermediate was successfully cyclized to the pyrimidoisoquinoline system.Reactions with 2,4-pentanedione and p-bromophenacyl bromide gave only the angular systems, pyridoisoquinoline and pyrroloisoquinoline, respectively.
