158688-66-5Relevant articles and documents
IMIDAZOLE-CONTAINING INHIBITORS OF ALK2 KINASE
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Page/Page column 634; 635, (2019/01/08)
Disclosed are compounds of formula (I), (II), (III), and (IV), and pharmaceutically acceptable salts thereof. The compounds are inhibitors of ALK2 kinase. Also provided are pharmaceutical compositions comprising a compound of formula (I), (II), (III), or (IV), or pharmaceutically acceptable salt thereof, and methods involving use of the compounds or pharmaceutically acceptable salts thereof and compositions in the treatment and prevention of various diseases and conditions, such as fibrodysplasia ossificans progressiva.
Reduction of 1-Aryl-4-Nitroimidazoles to 4-Amino-1-Arylimidazoles
Suwinski, J.,Walczak, K.
, p. 675 - 682 (2007/10/02)
1-aryl-4-nitroimidazoles on reduction with hydrogen in methanol at 25 degC, in the presence of Raney nickel, yield the unstable 4-amino-1-aryl-imidazoles which can be acylated e.g. with pentafluorophenyl formate, formic acid in the presence of dicyclohexy
