158693-01-7 Usage
Uses
Used in Pharmaceutical Industry:
(E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide is used as a pharmaceutical compound for its potential antimicrobial, anticancer, and anti-inflammatory properties. Its unique structure, which includes a cyano group and an acrylamide moiety, contributes to its diverse biological and pharmacological activities, making it a valuable asset in the development of new drugs and therapies.
Used in Biochemical Research:
In the field of biochemical research, (E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide is used as a research tool to study various biological processes and interactions. Its structural features, such as the nitro and hydroxy groups, allow it to be employed in investigations related to antioxidant and radical scavenging activities, providing valuable insights into the compound's potential applications in biotechnology and medicine.
Used in Antioxidant and Radical Scavenging Studies:
(E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide is used as a subject of study in antioxidant and radical scavenging research due to the presence of nitro and hydroxy groups in its structure. These groups suggest that the compound may have the ability to neutralize harmful free radicals and protect cells from oxidative damage, which could have significant implications for the development of novel antioxidant therapies and treatments for various diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 158693-01-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,8,6,9 and 3 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 158693-01:
(8*1)+(7*5)+(6*8)+(5*6)+(4*9)+(3*3)+(2*0)+(1*1)=167
167 % 10 = 7
So 158693-01-7 is a valid CAS Registry Number.
158693-01-7Relevant articles and documents
Arylcyanoacrylamides as inhibitors of the Dengue and West Nile virus proteases
Nitsche, Christoph,Steuer, Christian,Klein, Christian D.
, p. 7318 - 7337 (2012/01/05)
The 3-aryl-2-cyanoacrylamide scaffold was designed as core pharmacophore for inhibitors of the Dengue and West Nile virus serine proteases (NS2B-NS3). A total of 86 analogs was prepared to study the structure-activity relationships in detail. Thereby, it turned out that the electron density of the aryl moiety and the central double bond have a crucial influence on the activity of the compounds, whereas the influence of substituents of the amide residue is less relevant. The para-hydroxy substituted analog was found to be the most potent inhibitor in this series with a Ki-value of 35.7 μM at the Dengue and 44.6 μM at the West Nile virus protease. The aprotinin competition assay demonstrates a direct interaction of the inhibitor molecule with active centre of the Dengue virus protease. The target selectivity was studied in a counterscreen with thrombin and found to be 2.8:1 in favor of DEN protease and 2.3:1 in favor of WNV protease, respectively.
