15870-78-7

Basic information

• Product Name: 6-BROMO-2,4-DIMETHYL-1,2,4-TRIAZINE-3,5(2H,4H)-DIONE
• Synonyms: 6-Bromo-2,4-dimethyl-2H-[1,2,4]triazine-3,5-dione;6-bromo-2,4-dimethyl-2,3,4,5-tetrahydro-1,2,4-triazine-3,5-dione
• CAS NO: 15870-78-7
• Molecular Formula: C₅H₆BrN₃O₂
• Molecular Weight: 220.02
• Mol File: 15870-78-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 237.3°Cat760mmHg
• Flash Point: 97.3°C
• Appearance: /
• Density: 1.89g/cm³
• Vapor Pressure: 0.045mmHg at 25°C
• Refractive Index: 1.66
• PKA: -3.53±0.40(Predicted)
• CAS DataBase Reference: 6-BROMO-2,4-DIMETHYL-1,2,4-TRIAZINE-3,5(2H,4H)-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BROMO-2,4-DIMETHYL-1,2,4-TRIAZINE-3,5(2H,4H)-DIONE(15870-78-7)
• EPA Substance Registry System: 6-BROMO-2,4-DIMETHYL-1,2,4-TRIAZINE-3,5(2H,4H)-DIONE(15870-78-7)

Safety Data

• Hazardous Substances Data: 15870-78-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C5H6BrN3O2/c1-8-4(10)3(6)7-9(2)5(8)11/h1-2H3

Upstream product

• 4956-05-2 6-bromo-1,2,4-triazine-3,5(2H,4H)-dione 
• 74-88-4 methyl iodide 
• 15677-10-8 6-azido-1,3-dimethyluracil 

Downstream Products

• 909114-28-9 C₁₄H₁₈N₄O₃ 
• 1206516-43-9 6-[4-(2,5-bis-trifluoromethyl-benzoyl)-piperazin-1-yl]-2,4-dimethyl-2H-[1,2,4]triazine-3,5-dione 
• 909114-30-3 C₁₇H₂₁F₃N₄O₃ 
• 909114-29-0 C₁₈H₂₃F₃N₄O₃ 
• 909113-42-4 Ethyl 2-(4-{2-[(2,4-dimethyl-3,5-dioxo-2,3,4,5-tetrahydro-[1,2,4]triazin-6-yl)-(4,4,4-trifluoro-butyl)-amino]-ethyl}-phenoxy)-2-methyl-propionate 

Relevant articles and documents

DERIVATIVES OF TRIAZINES AND URACILS, THEIR PREPARATION AND THEIR APPLICATION IN HUMAN THERAPEUTICS

The present invention relates to derivatives of general formula I wherein : - W represents nitrogen, - R1 represents: ? a hydrogen or a linear or branched C1-C5 alkyl radical or, ? a C1-C3 alkyl radical substituted with groups such as trifluoromethyl, nitrile, hydroxy, C1-C3 alcoxy, C3-C6 alkoxyalkoxy, indolyl, thiophenyl, oxothiophenyl, C1-C3 N-alkylcarbamoyl groups or, ? a phenyl or pyridyl or naphthyl, or thiophenyl group optionally substituted with one or more groups such as halogen atoms, nitro, nitrile, trifluoromethyl, vinyl, methylsulfanyl, linear branched C1-C4 alkyl, linear or branched C1-C3 alkoxy groups, ? a C6 2-oxocycloalkyl radical - R2 represents a methyl or heptyl, - m, n are equal to 1, - V represents CH2, - X-Y represents -N- (C=O) -, -CH-O-, - Z represents a phenyl group substituted with one or more trifluoromethyl groups, halogen atoms or linear C1-C4 alkyl groups.

Cyclohexane derivatives difunctionalised in 1,4 as ligands of 5T H1A receptors

The invention concerns novel cyclohexane derivatives difunctionalised in 1.4 of general formula (1) in which A represents a group such as (IIa) in which Ar itself represents an aromatic structure such as phenyl or pyrimidinyl optionally substituted by one

Anticoccidial derivatives of 6 azauracil. I. Enhancement of activity by benzylation of nitrogen 1. Observations on the design of nucleotide analogues in chemotherapy

Benzylation of 6-azauracil at N-1 (which corresponds to the point of attachment of the ribose phosphate unit in pyrimidine nucleotides) has been found to augment its anticoccidial activity fourfold. The high potency of 1-benzyl-6-azauracil is ascribed to a combination of intrinsic activity, efficient oral absorption, and a moderate rate of excretion. Metabolism experiments using 1-benzyl-6-azauracil labeled with 14C in the heterocycle and (separately) in the side chain showed that, in the drug accounted for, no cleavage had occurred. Additional activity increases were achieved by introducing small, electron-withdrawing substituents in the meta and/or para position(s) of the benzyl group. One of the most active derivatives, 1-(3-cyanobenzyl)-6-azauracil, is about 16 times as potent as 6-azauracil.