158724-38-0Relevant academic research and scientific papers
Discovery and optimization of potent broad-spectrum arenavirus inhibitors derived from benzimidazole
Dai, Dongcheng,Burgeson, James R.,Gharaibeh, Dima N.,Moore, Amy L.,Larson, Ryan A.,Cerruti, Natasha R.,Amberg, Sean M.,Bolken, Tove C.,Hruby, Dennis E.
, p. 744 - 749 (2013/02/25)
A chemically diverse library of about 400,000 small molecules was screened for antiviral activity against lentiviral pseudotypes with the Lassa virus envelope glycoprotein (LASV GP) gene incorporated. High-throughput screening resulted in discovery of a h
Novel benzimidazole-based MCH R1 antagonists
Carpenter, Andrew J.,Al-Barazanji, Kamal A.,Barvian, Kevin K.,Bishop, Michael J.,Britt, Christy S.,Cooper, Joel P.,Goetz, Aaron S.,Grizzle, Mary K.,Hertzog, Donald L.,Ignar, Diane M.,Morgan, Ronda O.,Peckham, Gregory E.,Speake, Jason D.,Swain, Will R.
, p. 4994 - 5000 (2007/10/03)
The identification of an MCH R1 antagonist screening hit led to the optimization of a class of benzimidazole-based MCH R1 antagonists. Structure-activity relationships and efforts to optimize pharmacokinetic properties are detailed along with the demonstration of the effectiveness of an MCH R1 antagonist in an animal model of obesity.
