158732-53-7

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 5381-93-1 (4R)-4-hydroxy-4-phenylbutan-2-one 
• 1008412-19-8 C₁₆H₂₆OSi 
• 158732-43-5 (S)-2-(2-hydroxy-2-phenylethyl)-4-oxo-1,5-dioxaspiro<5.5>undec-2-one 
• 158732-52-6 4-[(R)-2-(tert-Butyl-dimethyl-silanyloxy)-2-phenyl-ethyl]-1,5-dioxa-spiro[5.5]undec-3-en-2-one 

Downstream Products

• 5381-93-1 (4R)-4-hydroxy-4-phenylbutan-2-one 
• 766546-95-6 (R)-4-(tert-butyldimethylsilanyloxy)-1-methylsulfanyl-4-phenylbutan-2-one 
• 766546-93-4 (R)-4-(tert-butyldimethylsilanyloxy)-1-chloro-4-phenylbutan-2-one 

Relevant academic research and scientific papers

QUINOLINE-OXAZOLINE COMPOUNDS AND THEIR USE IN OXIDATION SYNTHESIS

A quinoline-oxazoline compound having the formula: where one of X1 and X2 is N and the other is C and one of R1, R2 and R3 is Z wherein Z is an oxazoline radical having the formula such that when X1 is N R2 is Z and R1 is absent, and when X2 is N either R1 or R3 is Z and R2 is absent. R1 and R3 through R12 are independently H or a pendant moiety which does not interfere with coordination of either N in the quinoline compound with a coordination center. These compounds can be complexed with a suitable coordination center such as catalytically active palladium and can be highly useful in catalytically oxidizing alkenes with high regioselectivity.

A biocatalytic route to enantioenriched, sulfanyl aldol products

The aldol products derived from sulfur- or selenium containing acceptors were prepared by kinetic resolution in the presence of antibody 84G3 with enantiomeric excesses ranging from 56 to 70%. Much higher level of enantioselectivity was obtained (enantiomeric excesses all superior to 96%) for sulfanyl aldol products derived from thiomethoxyacetone with three different acceptors.

Use of 1,3-dioxin-4-ones and related compounds in synthesis. XLIV. Asymmetric aldol reaction of 4-trimethylsiloxy-6-methylene-1,3-dioxines: Use of tartaric acid-derived (acyloxy)borane complex as the catalyst

A novel enantioselective synthesis of 1,3-dioxin-4-ones having a 2-hydroxylated alkyl group at the 6-position has been accomplished by chiral tartaric acid-derived acylborane-mediated aldol condensation of the silyl enol ether derived from 6-methyl-derivatives of 1,3-dioxin-4-one with achiral aldehydes.