158741-04-9 Usage
Uses
Used in Pharmaceutical Industry:
(R)-2-amino-hexanol-(1); hydrochloride is used as a chiral building block for the development of various pharmaceuticals. Its ability to create enantiomer-specific compounds is crucial in the synthesis of drugs with targeted effects, reducing potential side effects and improving overall efficacy.
Used in Agrochemical Industry:
In the agrochemical sector, (R)-2-amino-hexanol-(1); hydrochloride serves as a key component in the synthesis of chiral pesticides and other agrochemicals. Its use ensures the development of more effective and environmentally friendly products by targeting specific pests while minimizing harm to non-target organisms.
Used in Organic Synthesis:
(R)-2-amino-hexanol-(1); hydrochloride is utilized as a crucial intermediate in organic chemistry, contributing to the synthesis of a wide range of fine chemicals. Its versatility and reactivity make it an indispensable tool in the development of new chemical compounds with various applications.
Used in Chiral Ligand and Catalyst Preparation:
(R)-2-amino-hexanol-(1); hydrochloride is employed as a vital component in the preparation of chiral ligands and catalysts, which are essential in asymmetric synthesis and other enantioselective reactions. The use of (R)-2-amino-hexanol-(1); hydrochloride in this context allows for the creation of more efficient and selective catalysts, leading to improved yields and enantiomeric purity in chemical reactions.
Used in Chiral Auxiliary Synthesis:
(R)-2-amino-hexanol-(1); hydrochloride is also used in the synthesis of chiral auxiliaries, which are temporary components added to a molecule during a chemical reaction to assist in controlling its stereochemistry. These auxiliaries are later removed, leaving behind the desired enantiomerically pure product. The use of (R)-2-amino-hexanol-(1); hydrochloride in chiral auxiliary synthesis aids in the development of more efficient and selective synthetic routes.
Check Digit Verification of cas no
The CAS Registry Mumber 158741-04-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,8,7,4 and 1 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 158741-04:
(8*1)+(7*5)+(6*8)+(5*7)+(4*4)+(3*1)+(2*0)+(1*4)=149
149 % 10 = 9
So 158741-04-9 is a valid CAS Registry Number.
158741-04-9Relevant academic research and scientific papers
Benzoxaborole Antimalarial Agents. Part 5. Lead Optimization of Novel Amide Pyrazinyloxy Benzoxaboroles and Identification of a Preclinical Candidate
Zhang, Yong-Kang,Plattner, Jacob J.,Easom, Eric E.,Jacobs, Robert T.,Guo, Denghui,Freund, Yvonne R.,Berry, Pamela,Ciaravino, Vic,Erve, John C. L.,Rosenthal, Philip J.,Campo, Brice,Gamo, Francisco-Javier,Sanz, Laura M.,Cao, Jianxin
, p. 5889 - 5908 (2017/07/22)
Carboxamide pyrazinyloxy benzoxaboroles were investigated with the goal to identify a molecule with satisfactory antimalarial activity, physicochemical properties, pharmacokinetic profile, in vivo efficacy, and safety profile. This optimization effort discovered 46, which met our target candidate profile. Compound 46 had excellent activity against cultured Plasmodium falciparum, and in vivo against P. falciparum and P. berghei in infected mice. It exhibited good PK properties in mice, rats, and dogs. It was highly active against the other 11 P. falciparum strains, which are mostly resistant to chloroquine and pyrimethamine. The rapid parasite in vitro reduction and in vivo parasite clearance profile of 46 were similar to those of artemisinin and chloroquine, two rapid-acting antimalarials. It was nongenotoxic in an Ames assay, an in vitro micronucleus assay, and an in vivo rat micronucleus assay when dosed orally up to 2000 mg/kg. The combined properties of this novel benzoxaborole support its progression to preclinical development.
