158743-83-0

Basic information

• Product Name: diphenylmethyl 7β-<(Z)-2-(2-tert-butoxycarbonylaminothiazol-4-yl)-4-phenyl-2-butenoylamino>-3-cephem-4-carboxylate
• CAS NO: 158743-83-0
• Molecular Weight: 708.859
• Mol File: 158743-83-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: diphenylmethyl 7β-<(Z)-2-(2-tert-butoxycarbonylaminothiazol-4-yl)-4-phenyl-2-butenoylamino>-3-cephem-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: diphenylmethyl 7β-<(Z)-2-(2-tert-butoxycarbonylaminothiazol-4-yl)-4-phenyl-2-butenoylamino>-3-cephem-4-carboxylate(158743-83-0)
• EPA Substance Registry System: diphenylmethyl 7β-<(Z)-2-(2-tert-butoxycarbonylaminothiazol-4-yl)-4-phenyl-2-butenoylamino>-3-cephem-4-carboxylate(158743-83-0)

Safety Data

• Hazardous Substances Data: 158743-83-0(Hazardous Substances Data)

Upstream product

• 36923-21-4 diphenylmethyl 7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 
• 158497-23-5 2-(2-tert-butoxycarbonylaminothiazol-4-yl)-4-phenyl-2(Z)-butenoic acid 
• 158743-69-2 (Z)-2-(2-tert-Butoxycarbonylamino-thiazol-4-yl)-4-phenyl-but-2-enoic acid benzhydryl ester 
• 97518-79-1 diphenylmethyl 2-(2-tert-butoxycarbonylimino-3-tert-butoxycarbonyl-1,3-thiazolin-4-yl)acetate 

Relevant articles and documents

Synthesis and structure-activity relationships of 7β-[(Z)-2-(2-aminothiazol-4-yl)-3-(substituted)-2- propenoyl-amino]-3-desacetoxymethylcephalosporins

Synthesis and biological activity of a series of 7β-[(Z)-2-(2-aminothiazol-4-yl)-3-(substituted)-2- propenoylamino]-3-cephem-4-carboxylic acids and their pivaloyloxymethyl esters are described. These acid compounds exhibited potent antibacterial activity against both Gram-positive and Gram-negative bacteria. Pivaloyloxymethyl esters of selected compounds in this series were found to be well absorbed from small intestine in mice.