158745-21-2Relevant academic research and scientific papers
Synthesis, structural characterization, crystallographic analysis and antibacterial properties of some nitrofuryl triazolo-1,3,4-thiadiazines
Holla, B. S.,Kalluraya, B.,Sridhar, K. R.,Drake, E.,Thomas, L. M.,et al,
, p. 301 - 308 (1994)
A series of 1-(5-nitro-2-furyl)-2-bromo-2-aryl-2-propen-1-ones has been prepared through dehydrobromination of 2,3-dibromo-1-(5-nitro-2-furyl)-3-arylpropan-1-ones.Condensation of 1-(5-nitro-2-furyl)-2-bromo-3-aryl-2-propen)-1-ones with 4-amino-5-mercapto-1,2,4-triazoles afforded a new class of 6-(5-nitro-2-furyl)-7-arylidene-1,2,4-triazolo-1,3,4-thiadiazines.The structure of the condensation products are fully confirmed by analytical, IR, NMR and mass spectral data.The formation of 1,2,4-triazolo-1,3,4-thiadiazines rather than 1,2,4-triazolo-1,3,4-thiadiazepines in the above condensation has also been confirmed by X-ray crystallographic analysis.The newly synthesized compounds have been screened for their in vitro antibacterial activity against Gram-positive and Gram-negative bacteria. antimicrobial agent / nitrofuran heterocycle / 1,2,4-triazole derivative
