158749-75-8

Usage

Uses

Used in Pharmaceutical Industry:
(R)-(-)-Hydroxy Chloroquine Diphosphate is used as an active pharmaceutical ingredient for the treatment of malaria. It is known for its effectiveness against Plasmodium parasites, which cause malaria.
Used in COVID-19 Research:
(R)-(-)-Hydroxy Chloroquine Diphosphate is used as a research compound for investigating its potential efficacy against the SARS-CoV-2 virus, which is responsible for the COVID-19 pandemic. Its antiviral properties are being studied to determine if it can be a viable treatment option for COVID-19 patients.

Upstream product

• 137433-23-9 (S)-Hydroxychloroquine 

Relevant academic research and scientific papers

Medicine for Covid-19 and treatment

The invention concerns a medicine and a prophylactic medicine for COVID-19 disease. The inventive medicine targets the endosomic, non-endosomic and/or intracellular viral pathways and inhibits them. The best mode of the invention is considered to be the medicine that blocks all three viral pathways. In the best mode the individual dose of a constituent component of the medicine is arranged to a dosage size sufficient to inhibit its designated SARS-CoV-2 viral pathway. This allows the dose of a particular pharmacological agent to be smaller than in a drug with just one kind of pharmacological agent. The best mode of the invention shuts the two cell membrane viral pathways and the one intracellular viral pathway with the minimum efficient dose, thereby preventing drug overdose, and enabling prophylactic or preventive use.

Asymmetric synthesis method of optically pure (R)/(S)-hydroxychloroquine

The present invention discloses an optical pure (R) / (S)-hydroxychloroqine asymmetric synthesis method, in order to 4-amino-7-chloroquinoline and 5-ethyl (2-hydroxyethyl) amine-2-pentanone as the starting raw material, under the catalysis of organic chemistry; apparatus, by asymmetric reduction reaction to obtain optically pure hydroxychloroqine, chiral acid control the stereo configuration of the three-dimensional configuration of the product. The method is simple, easy availability of raw materials, the yield is high, stereoselectivity is good, the operation is simple, chiral construction relatively low cost, is suitable for large-scale production. (by machine translation)