15875-60-2Relevant academic research and scientific papers
Revisiting the three component synthesis of isoxazolo[5,4-b]pyridines, 4-aryl-3,7,7-trimethyl-isoxazolo[5,4-b]quinolin-5(6H)-ones and related heterocycles
Lingham, Anthony R.,Hawley, John A.,Greaves, Tamar,Jackson, Neale,Antolasic, Frank,Hügel, Helmut M.
, p. 175 - 179 (2016)
The one-step three-component microwave assisted synthesis between aromatic aldehydes with tetronic acid or indan-1,3-dione readily formed the Knoevenagel adducts that underwent addition of 3-methylisoxazol-5-amine 1 to form the isoxazolo[5,4-b]pyridine pr
Microwave-promoted, catalyst-free, multi-component reaction of proline, aldehyde, 1,3-diketone: One pot synthesis of pyrrolizidines and pyrrolizinones
Manjappa, Kiran B.,Peng, Yu-Ting,Jhang, Wei-Fang,Yang, Ding-Yah
, p. 853 - 861 (2016)
One-pot, three-component preparation of the pyrrolizidine and pyrrolizinone derivatives in moderate to good yield is reported. The synthesis is facilitated by microwave irradiation of proline, aromatic aldehyde, and 1,3-diketone such as 2-arylmethylene-in
Mild Darzens Annulations for the Assembly of Trifluoromethylthiolated (SCF3) Aziridine and Cyclopropane Structures
Delost, Michael D.,Njardarson, Jon T.
supporting information, p. 6121 - 6125 (2021/08/16)
We report mild new annulation approaches to trisubstituted trifluoromethylthiolated (SCF3) aziridines and cyclopropanes via Darzens inspired protocols. The products of these anionic annulations, rarely studied previously, possess attractive features rendering them valuable building blocks for synthesis platforms. In this study, trisubstituted acetophenone nucleophiles bearing SCF3 and bromine substituents in their α position were shown to undergo [2 + 1] annulations with vinyl ketones and tosyl-protected imines under mild reaction conditions.
Synthesis of novel spiro-tetrahydroquinoline derivatives and evaluation of their pharmacological effects on wound healing
Liou, Yan-Cheng,Lin, Yan-An,Wang, Ke,Yang, Juan-Cheng,Jang, Yeong-Jiunn,Lin, Wenwei,Wu, Yang-Chang
, (2021/06/14)
A highly diastereoselective method for the synthesis of novel spiro-tetrahydroquinoline derivatives is reported here, using a one-pot reaction method. All compounds were characterized by1 H-nuclear magnetic resonance (NMR) and mass spectroscopy
Leishmanicidal and cytotoxic activities and 4D-QSAR of 2-arylidene indan-1,3-diones
de Souza, Ana P. M.,Costa, Maria C. A.,de Aguiar, Alex R.,Bressan, Gustavo C.,de Almeida Lima, Graziela D.,Lima, Wallace P.,Borsodi, Maria P. G.,Bergmann, Bartira R.,Ferreira, Márcia M. C.,Teixeira, Róbson R.
, (2021/08/03)
The indan-1,3-dione and its derivatives are important building blocks in organic synthesis and present important biological activities. Herein, the leishmanicidal and cytotoxicity evaluation of 16 2-arylidene indan-1,3-diones is described. The compounds w
Highly diastereoselective spiro-cyclopropanation of 2-arylidene-1,3-indanediones and dimethylsulfonium ylides
Huang, Jie,Lee, Kevin,Ma, Ping,Sun, Shaofa,Wang, Gangqiang,Wang, Jian,Wu, Yang,Xing, Yalan
supporting information, p. 18776 - 18780 (2021/10/26)
A highly diastereoselective spiro-cyclopropanation reaction of 2-arylidene-1,3-indanediones and dimethylsulfonium ylides has been developedviabase-induced annulation. This efficient and simple protocol features simple operations, mild conditions and excellent functional group compatibility. A variety of structurally interesting spiro-cyclopropanes were prepared in excellent yields and diastereomeric ratios (up to 97% yield and 20?:?1 dr). Also, ring expansion of the cyclopropanation product to quickly deliver a complex indeno[1,2-c]pyridazine structure showcased an interesting application of this method.
Phosphine-Catalyzed Cascade Michael Addition/[4+2] Cycloaddition Reaction of Allenoates and 2-Arylidene-1,3-indanediones
Shi, Wangyu,Mao, Biming,Xu, Jiaqing,Wang, Qijun,Wang, Wei,Wu, Yongjun,Li, Xuefeng,Guo, Hongchao
supporting information, p. 2675 - 2680 (2020/03/26)
The phosphine-catalyzed cascade Michael addition/[4+2] cycloaddition reaction of tetrahydrobenzofuranone-derived allenoates and 2-arylidene-1,3-indanediones has been reported, affording spirocyclic 1,3-indanedione derivatives in moderate to high yields wi
A vinylogous Michael addition-triggered quadruple cascade reaction for the enantioselective generation of multiple quaternary stereocenters
Yang, Shu-Mei,Karanam, Praneeth,Wang, Min,Jang, Yeong-Jiunn,Yeh, Yu-Sheng,Tseng, Ping-Yao,Ganapuram, Madhusudhan Reddy,Liou, Yan-Cheng,Lin, Wenwei
supporting information, p. 1398 - 1401 (2019/02/05)
An efficient organocatalytic quadruple cascade reaction resulting in spiroxindole scaffolds bearing five quaternary stereocenters is reported. The complex cascade reaction is triggered by the scarcely explored vinylogous Michael addition of 3-alkylidene o
Zirconium catalyzed synthesis of 2-arylidene Indan-1,3-diones and evaluation of their inhibitory activity against NS2B-NS3 WNV protease
Oliveira, Ana Flávia C. da S.,de Souza, Ana Paula M.,de Oliveira, André S.,da Silva, Milene L.,de Oliveira, Fabrício M.,Santos, Edjon G.,da Silva, ítalo Esposti P.,Ferreira, Rafaela S.,Villela, Filipe S.,Martins, Felipe T.,Leal, Daniel H.S.,Vaz, Boniek G.,Teixeira, Róbson R.,de Paula, Sergio O.
supporting information, p. 98 - 109 (2018/03/09)
A simple and efficient Knoevenagel procedure for the synthesis of 2-arylidene indan-1,3-diones is herein reported. These compounds were prepared via ZrOCl2·8H2O catalyzed reactions of indan-1,3-dione with several aromatic aldehydes and using water as the
Synthesis of highly functionalized indeno[1,2-b]furans
Dutta, Leema,Bhuyan, Pulak J.
, p. 3545 - 3548 (2017/10/06)
Some novel functionalized indeno[1,2-b]furans were synthesized from the reaction of indandione/indanone and aldehydes at room temperature followed by the reaction of the Knoevenagel condendensed intermediate with 4-hydroxycoumarins in the presence of iodi
