1587712-89-7Relevant academic research and scientific papers
Tetranuclear gadolinium(III) porphyrin complex as a theranostic agent for multimodal imaging and photodynamic therapy
Luo, Jian,Chen, Li-Feng,Hu, Ping,Chen, Zhong-Ning
, p. 4184 - 4191 (2014/05/06)
We describe herein the elaborate design of a Gd(III)-porphyrin complex as a theranostic agent for multimodal imaging and photodynamic therapy. Far-red-emitting (665 nm) and high relaxivity (14.1 mM-1 s -1) with 107% increase upon binding to HSA (human serum albumin) (29.2 mM-1 s-1) together with efficiently generating singlet oxygen upon exposure to far-red light irradiation at 650 ± 20 nm demonstrate that this Gd(III)-porphyrin complex with four Gd(III)-DTTA units bound to tetraphenylporphyrin acts as a potentially theranostic agent with excellent performance for magnetic resonance imaging, optical imaging, and photodynamic therapy.
