1587723-11-2

Upstream product

• 693803-22-4 5-chloro-3-iodoindole-2-carbaldehyde 
• 53590-49-1 5-chloro-1H-indole-2-carbaldehyde 

Relevant academic research and scientific papers

Three-step one-pot synthesis of 1,4-dihydropyrazolo[4,3-b]indoles using copper catalysis

A convenient three-step one-pot copper-catalysed method has been developed for the preparation of pyrazolo[4,3-b]indoles, new indole-based compounds with potential biological activity. Treatment of various hydrazines, including alkyl hydrazines, with indole-2-carbaldehydes generated the corresponding products in moderate to good yields without protection of the indole N-1 moiety. In addition, LiOH was used as a base in the copper-catalysed coupling reaction. Microwave heating was used to accelerate the iodination of indoles and the C-N bond formation. Diversely substituted pyrazolo[4,3-b]indoles, based on a new indole-containing skeleton, were prepared in a three-step one-pot procedure from unprotected indole-2-carbaldehydes and various hydrazines. LiOH was used as an alternative base in the copper-catalysed protocol. Copyright

Three-Step One-Pot Synthesis of 1,4-Dihydropyrazolo[4,3-b]indoles Using Copper Catalysis

A convenient three-step one-pot copper-catalysed method has been developed for the preparation of pyrazolo[4,3-b]indoles, new indole-based compounds with potential biological activity. Treatment of various hydrazines, including alkyl hydrazines, with indole-2-carbaldehydes generated the corresponding products in moderate to good yields without protection of the indole N-1 moiety. In addition, LiOH was used as a base in the copper-catalysed coupling reaction. Microwave heating was used to accelerate the iodination of indoles and the C-N bond formation. Diversely substituted pyrazolo[4,3-b]indoles, based on a new indole-containing skeleton, were prepared in a three-step one-pot procedure from unprotected indole-2-carbaldehydes and various hydrazines. LiOH was used as an alternative base in the copper-catalysed protocol.