158778-21-3

Basic information

• Product Name: CYCLO(-GLY-TYR(PO3H2)-VAL-PRO-MET-LEU)
• Synonyms: PDGF FRAGMENT (PHOSPHORYLATED) (CYCLIC);CYCLO(-GLY-TYR(H2PO3)-VAL-PRO-MET-LEU);CYCLO(-GLY-TYR(PO3H2)-VAL-PRO-MET-LEU)
• CAS NO: 158778-21-3
• Molecular Formula: C32H49N6O10PS
• Molecular Weight: 740.8
• Mol File: 158778-21-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.36±0.1 g/cm3(Predicted)
• Storage Temp.: -15°C
• PKA: 1.27±0.30(Predicted)
• CAS DataBase Reference: CYCLO(-GLY-TYR(PO3H2)-VAL-PRO-MET-LEU)(CAS DataBase Reference)
• NIST Chemistry Reference: CYCLO(-GLY-TYR(PO3H2)-VAL-PRO-MET-LEU)(158778-21-3)
• EPA Substance Registry System: CYCLO(-GLY-TYR(PO3H2)-VAL-PRO-MET-LEU)(158778-21-3)

Safety Data

• Hazardous Substances Data: 158778-21-3(Hazardous Substances Data)

Usage

General Description

CYCLO(-GLY-TYR(PO3H2)-VAL-PRO-MET-LEU) is a cyclic peptide containing the amino acids glycine, tyrosine (phosphorylated), valine, proline, methionine, and leucine. The phosphorylated tyrosine residue indicates that this peptide may be involved in cellular signaling pathways or other protein-protein interactions. The cyclic structure of the peptide may also provide stability and resistance to enzymatic degradation. This chemical has potential applications in drug development and research in the field of biochemistry and molecular biology.

Upstream product

• 92264-99-8 N^α-(tert-butoxycarbonyl)-O-(O',O''-dimethylphosphoro)-L-tyrosine 

Relevant articles and documents

Synthesis of Phosphonomethyl-phenylalanine and Phosphotyrosine Containing Cyclic Peptides as Inhibitors of Protein Tyrosine Kinase/SH2 Interactions.

Linear and cyclic hexameric peptides were synthesized with the amino acid sequence Gly-Tyr-Val-Pro-Met-Leu, which corresponds to the autophosphorylation segment around Y751 of PDGF receptor β subunit.The natural L-tyrosine (position 2) was also substituted in peptide analogs with D-Tyr, L-tyrosine phosphate, and L- and D-4-phosphonomethyl-phenylalanine (Pmp).Fmoc chemistry-based SPPS methodology, and Rink resin support were used with diphenylphosphoryl azide as the cyclizing agent.The linear and cyclic peptides were characterized by circular dichroism spectroscopy.The peptides described were designed as inhibitors of receptor tyrosine kinase/src homology region 2 interactions that mediate mitogenic signal transduction pathways.