158778-21-3 Usage
Uses
Used in Pharmaceutical Development:
CYCLO(-GLY-TYR(PO3H2)-VAL-PRO-MET-LEU) is used as a potential therapeutic agent for targeting specific cellular signaling pathways or protein interactions, due to its phosphorylated tyrosine residue and cyclic structure that may confer selectivity and stability.
Used in Biochemical Research:
In the field of biochemistry, CYCLO(-GLY-TYR(PO3H2)-VAL-PRO-MET-LEU) serves as a valuable research tool for studying the mechanisms of protein phosphorylation, protein-protein interactions, and the effects of cyclic peptides on cellular processes.
Used in Molecular Biology Applications:
CYCLO(-GLY-TYR(PO3H2)-VAL-PRO-MET-LEU) is utilized as a molecular probe to investigate the roles of specific amino acid sequences and post-translational modifications in biological systems, contributing to a deeper understanding of molecular mechanisms in biology.
Used in Drug Delivery Systems:
CYCLO(-GLY-TYR(PO3H2)-VAL-PRO-MET-LEU) may be employed in the design of drug delivery systems to improve the bioavailability and targeting of therapeutic agents, leveraging its cyclic structure for enhanced stability and resistance to degradation.
Used in Diagnostic Applications:
This cyclic peptide could be used as a diagnostic marker or in the development of assays to detect specific biological processes or diseases, capitalizing on its potential to interact with target molecules in a controlled manner.
Check Digit Verification of cas no
The CAS Registry Mumber 158778-21-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,8,7,7 and 8 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 158778-21:
(8*1)+(7*5)+(6*8)+(5*7)+(4*7)+(3*8)+(2*2)+(1*1)=183
183 % 10 = 3
So 158778-21-3 is a valid CAS Registry Number.
158778-21-3Relevant academic research and scientific papers
Synthesis of Phosphonomethyl-phenylalanine and Phosphotyrosine Containing Cyclic Peptides as Inhibitors of Protein Tyrosine Kinase/SH2 Interactions.
Nomizu, Motoyoshi,,Otaka, Akira,Burke, Terrence R.,Roller, Peter P.
, p. 2691 - 2702 (2007/10/02)
Linear and cyclic hexameric peptides were synthesized with the amino acid sequence Gly-Tyr-Val-Pro-Met-Leu, which corresponds to the autophosphorylation segment around Y751 of PDGF receptor β subunit.The natural L-tyrosine (position 2) was also substituted in peptide analogs with D-Tyr, L-tyrosine phosphate, and L- and D-4-phosphonomethyl-phenylalanine (Pmp).Fmoc chemistry-based SPPS methodology, and Rink resin support were used with diphenylphosphoryl azide as the cyclizing agent.The linear and cyclic peptides were characterized by circular dichroism spectroscopy.The peptides described were designed as inhibitors of receptor tyrosine kinase/src homology region 2 interactions that mediate mitogenic signal transduction pathways.
