15879-28-4

Usage

Uses

Used in Recreational Settings:
Ethanone, 1-(1H-indol-3-yl)-2-(methylamino)is used as a recreational substance for its psychedelic properties, providing users with unique experiences of euphoria, hallucinations, and altered perception.
Used in Research:
5-MeO-AMT is utilized in scientific research to study the effects of psychoactive substances on the central nervous system and their potential therapeutic applications.
Used in Controlled Substances Regulation:
Due to its psychoactive properties and potential for abuse, Ethanone, 1-(1H-indol-3-yl)-2-(methylamino)is classified as a controlled substance in many countries, requiring strict regulation and oversight to prevent misuse and associated health risks.

Upstream product

• 487-89-8 Indole-3-carboxaldehyde 
• 444108-97-8 2-(1H-indol-3-yl)-2-((trimethylsilyl)oxy)acetonitrile 
• 87084-40-0 2-amino-1-(1H-indol-3-yl)ethan-1-one 
• 74-88-4 methyl iodide 

Relevant academic research and scientific papers

The potential of achiral sponge-derived and synthetic bromoindoles as selective cytotoxins against PANC-1 tumor cells

Our quest to isolate and characterize natural products with in vitro solid tumor selectivity is driven by access to repositories of Indo-Pacific sponge extracts. In this project an extract of a species of Haplosclerida sponge obtained from the US NCI Natural Products Repository displayed, by in vitro disk diffusion assay (DDA) and IC50 determinations, selective cytotoxicity with modest potency to a human pancreatic cancer cell line (PANC-1) relative to the human lymphoblast leukemia cell line (CCRF-CEM). Two brominated indoles, the known 6-bromo conicamin (1) and the new derivative, 6-Br-8-keto-conicamin A (2), were identified and 2 (IC50 1.5 μM for the natural product vs 4.1 μM for the synthetic material) was determined to be responsible for the cytotoxic activity of the extract against the PANC-1 tumor cell line. The new natural product and ten additional analogs were prepared for further SAR testing.