158809-43-9Relevant academic research and scientific papers
Amide bond formation via pentafluorothiophenyl active esters
Davis, Anthony P.,Walsh, John J.
, p. 4865 - 4868 (2007/10/02)
A number of pentafluorothiophenyl (PFTP) esters were shown to be useful acyl donors for amide bond formation, being non-polar, stable to chromatography and extended storage, but sufficiently active for use with relatively unreactive acyl groups. In partic
7-oxabicycloheptyl substituted heterocyclic amide or ester prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease
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, (2008/06/13)
7-Oxabicycloheptane substituted prostaglandin analogs useful in treating thrombotic and vasopastic disease have the structural formula STR1 wherein m is 1, 2 or 3; n is 1, 2, 3 or 4; Z is --(CH2)2 --, --CH=CH-- or STR2 wherein Y is O, a single bond or vinyl, with the proviso that when n is 0, if Z is STR3 then Y cannot be O, and Z is --CH=CH--, n is 1, 2, 3 or 4; and when Y=vinyl, n=0; R is CO2 H, CO2 lower alkyl, CH2 OH, CO2 alkali metal, CONHSOR3, CONHR3a or --CH2 --5-tetrazolyl, X is O, S or NH; and where R1, R2, R3 and R3a are as defined herein.
