1588421-61-7

Basic information

• Product Name: (R)-3-[(2-hydroxyphenyl)thio]-1,2-epoxypropane
• Synonyms: (R)-3-[(2-hydroxyphenyl)thio]-1,2-epoxypropane
• CAS NO: 1588421-61-7
• Molecular Weight: 182.243
• Mol File: 1588421-61-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-3-[(2-hydroxyphenyl)thio]-1,2-epoxypropane(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-[(2-hydroxyphenyl)thio]-1,2-epoxypropane(1588421-61-7)
• EPA Substance Registry System: (R)-3-[(2-hydroxyphenyl)thio]-1,2-epoxypropane(1588421-61-7)

Safety Data

• Hazardous Substances Data: 1588421-61-7(Hazardous Substances Data)

Upstream product

• 1121-24-0 ortho-mercaptophenol 
• 67843-74-7 (S)-epichlorohydrin 

Relevant articles and documents

Stereospecific alkylation of substituted adenines by the Mitsunobu coupling reaction under microwave-assisted conditions

A novel and efficient synthetic method has been developed for the preparation of alkylated aminopurines (N,N-dimethyl-, 2-chloro-N-methyl-, and N-methyladenines) with achiral and chiral 3,4-dihydro-2H-1,5-benzoxathiepin-3-ol by the Mitsunobu reaction under microwave-assisted conditions. This reaction reveals a complete inversion of the stereogenic centre of the secondary alcohol giving an alkylated purine linked to a homochiral six-membered ring. Fifty novel purine derivatives have been prepared. Alkylation sites have been determined by 2D NMR techniques and for three compounds have been confirmed by X-ray crystallography. The N-9/N-3 regioselectivity can be justified by the electronic effects of the substituents at positions 2 and 6 of the purine. This journal is the Partner Organisations 2014.