1588490-32-7

Basic information

• Product Name: 3-(4-hydroxyphenyl)-N-(quinolin-8-yl)propanamide
• Synonyms: 3-(4-hydroxyphenyl)-N-(quinolin-8-yl)propanamide
• CAS NO: 1588490-32-7
• Molecular Weight: 292.337
• Mol File: 1588490-32-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(4-hydroxyphenyl)-N-(quinolin-8-yl)propanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-hydroxyphenyl)-N-(quinolin-8-yl)propanamide(1588490-32-7)
• EPA Substance Registry System: 3-(4-hydroxyphenyl)-N-(quinolin-8-yl)propanamide(1588490-32-7)

Safety Data

• Hazardous Substances Data: 1588490-32-7(Hazardous Substances Data)

Upstream product

• 106-41-2 4-bromo-phenol 
• 33757-46-9 8-(N-propionylamino)quinoline 

Downstream Products

• 81147-94-6 methyl 3-<4-(2,3-epoxypropoxy)phenyl>propionate 
• 81147-92-4 esmolol 
• 5597-50-2 3-(4-hydroxyphenyl)propionic acid methyl ester 

Relevant articles and documents

Pd(II)-catalyzed intermolecular arylation of unactivated C(sp 3)-H bonds with aryl bromides enabled by 8-aminoquinoline auxiliary

An example of using readily available, less reactive aryl bromides as arylating reagents in the Pd(II)-catalyzed intermolecular arylation of unactivated C(sp3)-H bonds is described. This reaction was promoted by a crucial 8-aminoquinolinyl directing group and a K2CO3 base, enabling regiospecific installation of an aryl scaffold at the β-position of carboxamides. A mechanistic study by DFT calculations reveals a C(sp3)-H activation-led pathway featuring the oxidative addition as the highest energy transition state.