15885-04-8

Basic information

• Product Name: 1-(4-methylpiperazin-1-yl)acetone
• Synonyms: 1-(4-methylpiperazin-1-yl)acetone;Albb-003774;1-(4-methyl-1-piperazinyl)acetone(SALTDATA: FREE)
• CAS NO: 15885-04-8
• Molecular Formula: C₈H₁₆N₂O
• Molecular Weight: 156.23
• Mol File: 15885-04-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 224.196°C at 760 mmHg
• Flash Point: 82.407°C
• Appearance: /
• Density: 0.978g/cm³
• Vapor Pressure: 0.092mmHg at 25°C
• Refractive Index: 1.466
• PKA: 7.45±0.10(Predicted)
• CAS DataBase Reference: 1-(4-methylpiperazin-1-yl)acetone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-methylpiperazin-1-yl)acetone(15885-04-8)
• EPA Substance Registry System: 1-(4-methylpiperazin-1-yl)acetone(15885-04-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 15885-04-8(Hazardous Substances Data)

Usage

General Description

1-(4-methylpiperazin-1-yl)acetone, also known as 4-Methyl-1-piperazineacetone, is a chemical compound with the molecular formula C8H16N2O. It is a clear, colorless liquid with a faint odor, and is commonly used as an intermediate in the synthesis of pharmaceuticals and organic compounds. 1-(4-methylpiperazin-1-yl)acetone is often utilized as a building block in the production of various drugs, including antihistamines and antipsychotic medications. It is also used as a reagent in organic chemistry reactions and as a solvent in chemical processes. Due to its versatile nature and wide range of applications, 1-(4-methylpiperazin-1-yl)acetone is a valuable chemical compound in the pharmaceutical and chemical industries.

InChI:InChI=1/C8H16N2O/c1-8(11)7-10-5-3-9(2)4-6-10/h3-7H2,1-2H3

Upstream product

• 109-01-3 1-methyl-piperazine 
• 2684-62-0 diazoacetone 
• 56-81-5 glycerol 
• 598-31-2 1-bromoacetone 
• 78-95-5 chloroacetone 

Downstream Products

• 101455-09-8 (E)-4-(4-Methoxy-phenyl)-1-(4-methyl-piperazin-1-yl)-but-3-en-2-ol 

Relevant articles and documents

Glycerol as a Building Block for Prochiral Aminoketone, N-Formamide, and N-Methyl Amine Synthesis

Prochiral aminoketones are key intermediates for the synthesis of optically active amino alcohols, and glycerol is one of the main biomass-based alcohols available in industry. In this work, glycerol was catalytically activated and purposefully converted with amines to generate highly valuable prochiral aminoketones, as well as N-formamides and N-methyl amines, over CuNiAlOx catalyst. The catalyst structure can be anticipated as nano-Ni species on or in CuAlOx via the formation of nano- Cu?Ni alloy particles. This concept may present a novel and valuable methodology for glycerol utilization.

Expeditious one-pot synthesis of C3-piperazinyl-substituted quinolines: Key precursors to potent c-Met inhibitors

An effective one-pot synthesis of quinolines bearing diverse C3-piperazinyl functions was developed by using a modified Friedlaender's protocol. The method not only enables the synthesis of our early reported c-Met inhibitor on a large scale, but also provides a way to generate novel multi-substituted quinolines for further structure-activity relationship (SAR) study.