158861-38-2Relevant articles and documents
MACROCYCLIC THERAPEUTIC AGENTS, METHODS OF MANUFACTURE, AND METHODS OF TREATMENT
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Page/Page column 75; 76; 78, (2015/09/28)
The instant invention describes macrocyclic compounds having therapeutic activity, and the mechanism and methods of treating disorders such as autoimmune diseases, inflammation, and cancer, tumors and cell proliferation related disorders.
Convergent synthesis of peptide nucleic acids by native chemical ligation
Dose, Christian,Seitz, Oliver
, p. 4365 - 4368 (2007/10/03)
(Chemical Equation Presented) A convergent strategy for synthesizing long contiguous PNA by a native chemical ligation-like technique of PNA segment couplings is presented. This approach required the synthesis of a new PNA-monomer featuring a 1-amino-2-th
Pseudopeptide Inhibitors of Ras Farnesyl-Protein Transferase
Graham, Samuel L.,deSolms, S. Jane,Giuliani, Elizabeth A.,Kohl, Nancy E.,Mosser, Scott D.,et al.
, p. 725 - 732 (2007/10/02)
Inhibitors of Ras farnesyl-protein transferase are described.These are reduced pseudopeptides related to the C-terminal tetrapeptide of the Ras protein that signals farnesylation.Deletion of the carbonyl groups between the first two residues of the tetrap