15887-84-0Relevant academic research and scientific papers
Photoisomerization in an analogous set of ruthenium sulfoxide complexes
Porter, Brianne L.,McClure, Beth Anne,Abrams, Eric R.,Engle, James T.,Ziegler, Christopher J.,Rack, Jeffrey J.
experimental part, p. 341 - 346 (2011/11/04)
Complexes of the type [Ru(bpy)2(OSOBnR)](PF6) where bpy is 2,2′-bipyridine and OSOBnR is a 4-substituted benzylsulfinylbenzoate with R = NO2, F, Cl, H, CH3, CF3 and OCH3, have been prepared
Design and synthesis of new 2-substituted-5-(2-benzylthiophenyl)-1,3,4- oxadiazoles as benzodiazepine receptor agonists
Zarghi, Afshin,Faizi, Mehrdad,Shafaghi, Bijan,Ahadian, Avideh,Khojastehpoor, Hamid R.,Zanganeh, Vahideh,Tabatabai, Sayyed A.,Shafiee, Abbas
, p. 3126 - 3129 (2007/10/03)
A series of new 2-substituted-5-(2-benzylthiophenyl)-1,3,4-oxadiazoles was designed and synthesized as anticonvulsant agents. Conformational analysis and superimposition of energy minima conformers of the designed molecules on estazolam, a known benzodiazepine receptor agonist, revealed that the main proposed benzodiazepine pharmacophores were well matched. Electroshock and pentylenetetrazole-induced lethal convulsion tests showed that the introduction of an amino group in position 2 of 1,3,4-oxadiazole ring and a fluoro substituent at para position of benzylthio moiety had the best anticonvulsant activity. It seems this effect is mediated through benzodiazepine receptors mechanism.
