158875-49-1Relevant academic research and scientific papers
An approach to 1-alkyl-3-phenylpiperidine derivatives containing 2,5- functionalized groups: 1-Methyl-2-(4-chlorophenylthiomethyl)-5- (metoxycarbonyl)-piperidine
Kotzamani,Gourdoupis,Stamos
, p. 10477 - 10482 (1994)
Compound 6 was synthesized by regiospecific addition of 4- chlorothiophenol to diazoketone 5 in the presence of a rhodium (II) acetate catalyst. An annelation process presumably proceeded via initial attack of methylamine on the bromoacrylic ester to give
