158877-59-9

Basic information

• Product Name: N-chloromethyl-N-(ethoxycarbonylmethyl)benzamide
• Synonyms: N-chloromethyl-N-(ethoxycarbonylmethyl)benzamide
• CAS NO: 158877-59-9
• Molecular Weight: 255.701
• Mol File: 158877-59-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-chloromethyl-N-(ethoxycarbonylmethyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-chloromethyl-N-(ethoxycarbonylmethyl)benzamide(158877-59-9)
• EPA Substance Registry System: N-chloromethyl-N-(ethoxycarbonylmethyl)benzamide(158877-59-9)

Safety Data

• Hazardous Substances Data: 158877-59-9(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 1499-53-2 ethyl hippurate 

Downstream Products

• 158877-62-4 2-(6-Methoxy-naphthalen-2-yl)-propionic acid (benzoyl-ethoxycarbonylmethyl-amino)-methyl ester 
• 158877-63-5 2-(4-Isobutyl-phenyl)-propionic acid (benzoyl-ethoxycarbonylmethyl-amino)-methyl ester 
• 202343-49-5 N-(ethoxycarbonylmethyl)benzamidomethyl benzoate 

Relevant articles and documents

A New Direct Synthesis of Tertiary N-Acyloxymethylamide Prodrugs of Carboxylic Acid Drugs

N-Alkyl-N-chloromethylamides 2, prepared from secondary amides, paraformaldehyde and chlorotrimethylsilane, react readily with carboxylate anions to generate the corresponding tertiary N-acyloxymethylamides 3 in good yield; the latter give rise to the parent carboxylic acids in aqueous media at pH 7.4 and 37 deg C with half-lives between ca. 1 min and 42 h.