158890-32-5

Basic information

• Product Name: 1-(4-BENZYL-PIPERIDIN-1-YL)-2-CHLORO-ETHANONE
• Synonyms: TIMTEC-BB SBB011960;1-(4-BENZYL-PIPERIDIN-1-YL)-2-CHLORO-ETHANONE;4-benzyl-1-(chloroacetyl)piperidine
• CAS NO: 158890-32-5
• Molecular Formula: C₁₄H₁₈ClNO
• Molecular Weight: 251.75
• Mol File: 158890-32-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 392.6±25.0 °C(Predicted)
• Appearance: /
• Density: 1.152±0.06 g/cm3(Predicted)
• PKA: -0.95±0.40(Predicted)
• CAS DataBase Reference: 1-(4-BENZYL-PIPERIDIN-1-YL)-2-CHLORO-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-BENZYL-PIPERIDIN-1-YL)-2-CHLORO-ETHANONE(158890-32-5)
• EPA Substance Registry System: 1-(4-BENZYL-PIPERIDIN-1-YL)-2-CHLORO-ETHANONE(158890-32-5)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 158890-32-5(Hazardous Substances Data)

Usage

General Description

1-(4-benzyl-piperidin-1-yl)-2-chloro-ethanone is a chemical compound with the molecular formula C16H20ClNO. It is a ketone that contains a piperidine ring with a benzyl and chloro substitution. It is commonly used as an intermediate in the synthesis of various pharmaceuticals and organic compounds. This chemical is known for its pharmacological properties and is being studied for its potential use in the treatment of various medical conditions. It is important for researchers and chemists to handle this compound with care and follow proper safety protocols due to its potential hazards and reactivity.

Upstream product

• 31252-42-3 4-benzylpyperidine 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 349087-39-4 N-[2-(4-benzylpiperidin-yl)-2-oxoethyl]phthalimide 
• 1367355-26-7 2-azido-1-(4-benzylpiperidin-1-yl)ethanone 
• 1379795-13-7 1-(4-benzylpiperidin-1-yl)-2-(3-nitro-1H-1,2,4-triazol-1-yl)ethan-1-one 
• 904508-37-8 C₂₇H₂₈N₄O₃S 
• 202124-60-5 2-amino-1-(4-benzylpiperidin-1-yl)ethan-1-one 
• 202124-61-6 4-[(4-benzylpiperidinecarbonyl)methyl]amino-3-nitrobenzonitrile 

Relevant articles and documents

AN ACTIVITY-GUIDE MAP OF ELECTROPHILE-CYSTEINE INTERACTIONS IN PRIMARY HUMAN IMMUNE CELLS

Disclosed herein are methods, pharmaceutical compositions, and vaccines for modulating an immune response. Also disclosed herein are methods, pharmaceutical compositions, and vaccines for inducing an immune response.

Novel 3-nitro-1 H -1,2,4-triazole-based amides and sulfonamides as potential antitrypanosomal agents

A series of novel 3-nitro-1H-1,2,4-triazole-based (and in some cases 2-nitro-1H-imidazole-based) amides and sulfonamides were characterized for their in vitro antitrypanosomal and antileishmanial activities as well as mammalian toxicity. Out of 36 compounds tested, 29 (mostly 3-nitro-1H-1,2,4-triazoles) displayed significant activity against Trypanosoma cruzi intracellular amastigotes (IC50 ranging from 28 nM to 3.72 μM) without concomitant toxicity to L6 host cells (selectivity 66-2782). Twenty-three of these active compounds were more potent (up to 58-fold) than the reference drug benznidazole, tested in parallel. In addition, nine nitrotriazoles which were moderately active (0.5 μM ≥ IC50 6.0 μM) against Trypanosoma brucei rhodesiense trypomastigotes were 5-31-fold more active against bloodstream-form Trypanosoma brucei brucei trypomastigotes engineered to overexpress reduced nicotinamide adenine dinucleotide dependent nitroreductase. Finally, three nitrotriazoles displayed a moderate activity against the axenic form of Leishmania donovani. Therefore, 3-nitro-1H-1,2,4-triazole-based amides and sulfonamides are potent antitrypanosomal agents.

Pyridazinone derivatives with pharmaceutical activity

A 3(2H)-pyridazinone derivative of the formula (I) its salt, a process for its production and a pharmaceutical composition containing it. STR1 wherein each of R1, R2 and R3 which are independent of one another, is a hydrogen atom or a C1-4 alkyl group, X is a chlorine atom or a bromine atom, Y1 is a hydrogen atom, a halogen atom, a nitro group, an amino group or a C1-4 alkoxy group, Y2 is a hydrogen atom, a halogen atom, a hydroxyl group, a C1-4 alkyl group or a C1-4 alkoxy group, A is a C1-5 alkylene chain which may be substituted by a hydroxyl group, B is a carbonyl group or a methylene chain which may be substituted by a C1-4 alkyl group, and each of R4 and R5 which are independent of each other, is a C1-4 alkyl group, or R4 is a hydrogen atom and R5 is --Z--Ar (wherein Z is a C1-5 alkylene chain, and Ar is an aromatic 6-membered ring which may contain a nitrogen atom), or R4 and R5 together form a C2-6 cyclic alkylene group, or R4 and R5 form together with the adjacent nitrogen atom a 4-substituted piperazine ring of the formula: STR2 wherein R6 is a C1-4 alkyl group.