1588972-68-2

Upstream product

• 768-60-5 4-methoxyphenylacetylen 
• 1001334-22-0 5-chloro-2-iodobenzaldehyde 
• 115-19-5 2-methyl-but-3-yn-2-ol 
• 1588973-18-5 C₂₁H₁₉ClO₃ 

Downstream Products

• 1588971-97-4 7'-chloro-3,4,4'-triiodo-3'-(4-methoxyphenyl)-5,5-dimethyl-5H-spiro[furan-2,1'-isochromene] 
• 1588972-33-1 4,7'-dichloro-3,4'-diiodo-3'-(4-methoxyphenyl)-5,5-dimethyl-5H-spiro[furan-2,1'-isochromene] 

Relevant academic research and scientific papers

Facile synthesis of halogenated spiroketals via a tandem iodocyclization

A strategy for the synthesis of spiroketal compounds through a tandem iodocyclization of 1-(2-ethynylphenyl)-4-hydroxybut-2-yn-1-one derivatives is presented. This reaction could proceed under very mild conditions in a short time and avoid the use of expensive and toxic metal catalysts. Moreover, the resulting halides can be further exploited by subsequent palladium-catalyzed coupling reactions, which act as the important intermediates for building other valuable compounds.