158937-79-2

Upstream product

• 75-21-8 oxirane 
• 78197-28-1 4-Cyclohexylmethyl-piperidine 

Downstream Products

• 158937-98-5 4'-(2-[4-cyclohexylmethylpiperidine-1-yl]ethoxy)-[1,1'-biphenyl]-4-ylcarboxylic acid 

Relevant academic research and scientific papers

Cyclohexapeptidyl amine compounds

Cyclohexapeptidyl amine compounds are disclosed of the formula: or its acid addition salt, wherein: R1is H or OH; R2is H or OH; R3is QCnH2nNRVRVI, QCnH2nNRVRVIRVII+Y?, or Q(CH2)1-3CRVIIIRIXNHRX. R4is H or OH; R5is H, OH or CH3; R6is H or CH3; RIis wherein Rais C1-C10alkyl; or (CH2)qNRbRcwherein Rband Rcare independently H, C1-C10alkyl or Rband Rctaken together are wherein Rdis C1-C16alkyl, phenyl or benzyl; RIIis H, C1-4alkyl or benzyl; RIIIis H, C1-4alkyl or benzyl; RIVis RIIand RIIItaken together as —(CH2)4— or —(CH2)5—; RVis H, C1-C4alkyl or benzyl; RVIis H, C1-C4alkyl or benzyl or RVand RVItogether is —(CH2)4— or —(CH2)5—; RVIIis H or C1-C4alkyl; RVIIIis H, (CH2)mH, (CH2)mOH, (CH2)mNH2or COX wherein X is NH2, OH or O(CH2)mH; RIXis H, (CH2)mH, or together with RVIIIis ═O (carbonyl); RXis H (except when RVIIIand RIXare H, C(═NH)NH2, C(═NH)CH2)0-3H, CO(CH2)0-3H, CO(CH2)mNH2, (CH2)2-4OH or (CH2)2-4NH2; Q is O or S; Y is an anion of a pharmaceutically acceptable salt each m is independently an integer from 1 to 3, inclusive; n is an integer from 2 to 4, inclusive; p is an integer from 1 to 2, inclusive and q is an integer from 2 to 4, inclusive.

Cyclohexapeptidyl propanolamine compounds

Certain propanolamine compounds are described which have a cyclohexapeptidyl nucleus and which possess antibiotic activity with physical properties suitable for direct use in therapeutic compositions. A process for their preparation is also described.

Cyclohexapeptidyl aminoalkyl ethers

There are disclosed compounds of the general formula STR1 wherein all substituents are defined herein. The compounds are useful as antibiotic and antifungal agents.

Antifungal cyclohexapeptides

The present invention is directed to novel carba cyclohexapeptide compounds of the formula STR1 where all substituents are defined herein, which are useful as antifungal agents and for the treatment of Pneumocystis carinii infections. Compositions containing the compounds of the invention are also disclosed.

Aza cyclohexapeptide compounds

The present invention relates to aza cyclohexapeptide compounds of the formula (Seq ID Nos. 1-10) STR1 which may be useful as antibiotics, antifungal agents and for the treatment of Pneumocystis carinii infections.

Aza cyclohexapeptide compounds

The present invention is directed to novel aza cyclohexapeptide compounds of the formula STR1 where all substituents are defined herein, which are useful as antifungal agents and for the treatment of Pneumocystis carinii infections. Compositions containing the compounds of the invention are also disclosed.