158944-95-7Relevant academic research and scientific papers
2-Cyano-4-fluoro-1-thiovalylpyrrolidine analogues as potent inhibitors of DPP-IV
Haffner, Curt D.,McDougald, Darryl L.,Reister, Steven M.,Thompson, Brian D.,Conlee, Christopher,Fang, Jing,Bass, Jonathan,Lenhard, James M.,Croom, Dallas,Secosky-Chang, Melissa B.,Tomaszek, Thaddeus,McConn, Donavon,Wells-Knecht, Kevin,Johnson, Paul R.
, p. 5257 - 5261 (2008/12/23)
We report the synthesis and biological activity of a series of 2-cyano-4-fluoro-1-thiovalylpyrrolidine inhibitors of DPP-IV. Within this series, compound 19 provided a potent, selective, and orally active DPP-IV inhibitor which demonstrated a very long duration of action in both rat and dog.
Preparation of Some Novel S-Nitroso Compounds as Potential Slow-release Agents of Nitric Oxide in vivo
Moynihan, Humphrey A.,Roberts, Stanley M.
, p. 797 - 806 (2007/10/02)
The optimum conditions for the preparation of N-acetyl-S-nitrosopenicillamine (SNAP) 3 were determined and applied to the synthesis of the corresponding N-formyl compound 7.The nitrosation of penicillamine dipeptides was investigated and bis-thionitroso compounds 13, 18, 26 and 27 were isolated.S,S'-Dinitroso dithiol 13 showed biological activity akin to that of glyceryl trinitrate in decreasing systemic arterial blood pressure in anaesthetized rats and rabbits.Concomitant inhibition of collagen- or ADP-induced platelet aggregation was observed.
