1589534-35-9

Upstream product

• 132971-93-8 2'-hydroxy-4-chlorochalcone 
• 70-11-1 α-bromoacetophenone 
• 1589534-64-4 C₂₃H₁₇ClO₃ 
• 90-02-8 salicylaldehyde 
• 98-80-6 phenylboronic acid 
• 99-91-2 para-chloroacetophenone 
• 132971-93-8 (E)-1-(4-chlorophenyl)-3-(2-hydroxyphenyl)prop-2-en-1-one 

Relevant academic research and scientific papers

Palladium-Catalyzed Cascade Reactions of 2-(Cyanomethoxy)chalcones with Arylboronic Acids: Selective Synthesis of Emissive Benzofuro[2,3- c]pyridines

The Pd(II)-catalyzed cascade reactions of 2-(cyanomethoxy)chalcones with arylboronic acids were demonstrated, allowing the rapid construction of benzofuro[2,3-c]pyridine skeletons with excellent selectivity. These transformations involve the domino-style formation of C-C/C-C/C-N bonds through nitrile carbopalladation, intramolecular Michael addition, cyclization, and aromatization. This chemistry allows for the reactions of 2-(cyanomethoxy)chalcones with thiophen-3-ylboronic acid, providing 3-aryl-1-(thiophen-3-yl)benzofuro[2,3-c]pyridines in moderate to good yields. In addition, the resulting products represent a new class of emissive fluorophores.

A facile approach for synthesis of benzofuro[2,3-c]pyridines via intramolecular cascade annulations

A facile synthesis of benzofuro[2,3-c]pyridines has been achieved under mild conditions by using ammonium acetate as the nitrogen source through intramolecular cascade annulation. This reaction could efficiently construct pyridine ring and furan ring in o

Clean and efficient assembly of functionalized benzofuro[2,3-c]pyridines via metal-free one-pot domino reactions

A clean and efficient method for the domino synthesis of new functionalized benzofuro[2,3-c]pyridines from easily accessible 2-hydroxychalcones, α-bromo ketones and ammonium acetate is described. Furan and pyridine ring moieties are ingeniously formed in

Synthesis of benzofuro[2,3-c]pyridines via a one-pot three-component reaction

A convenient one-pot reaction was conducted by mixing bromoacetophenone, a functionalized α,β-unsaturated ketone and potassium hydroxide in tetrahydrofuran at room temperature, ammonium acetate was added and heated to reflux, resulting in four chemical bonds forming from easily accessible substrates. This process provides a flexible and rapid synthetic route for the construction of polysubstituted benzofuro[2,3-c]pyridines in moderate to good yields. This journal is the Partner Organisations 2014.