1589574-33-3Relevant academic research and scientific papers
Iodine-promoted synthesis of 1-alkyl-3-aroylindolizines from N-(Aroylmethyl)pyridinium salts and aliphatic aldehydes
Tan, Chen,Yan, Peiyun,Ye, Weijian,Yao, Juan,Wu, Weiming,Wang, Cunde
, p. 72 - 81 (2014/02/14)
An effective and practical method has been developed for the diversity-oriented synthesis of 1-alkyl-3-aroylindolizines via the 1,3-dipolar cycloaddition of pyridinium ylides and aliphatic aldehydes in the presence of molecular iodine and a catalytic amount of MnO2. The synthesis proceeds by tandem reactions involving [3+2] cycloaddition, dehydration of the cycloadduct, and dehydroaromatization. Molecular iodine served both as a catalyst and a dehydroaromatization reagent in the reaction.
