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Usage

Uses

Used in Pharmaceutical Industry:
1-(3-METHOXY-4,5-METHYLENEDIOXYPHENYL)-2-NITROETHANE is used as a precursor chemical for the synthesis of [application reason] a variety of psychoactive substances, including certain amphetamine and MDMA derivatives. Its role in the production of these substances is crucial, as it serves as a foundational component in their chemical structure.
Used in Research and Development:
In the field of scientific research, 1-(3-METHOXY-4,5-METHYLENEDIOXYPHENYL)-2-NITROETHANE is used as a research compound for [application reason] studying the effects and mechanisms of action of psychoactive substances. This helps researchers gain a deeper understanding of these compounds and potentially develop new treatments for various conditions.

InChI:InChI=1/C10H9NO5/c1-14-8-4-7(2-3-11(12)13)5-9-10(8)16-6-15-9/h2-5H,6H2,1H3/b3-2-

Upstream product

• 75-52-5 nitromethane 
• 5780-07-4 3-methoxy-4,5-methylenedioxybenzaldehyde 
• 3934-87-0 5-hydroxyvanillin 
• 5438-36-8 5-iodovaniline 
• 121-33-5 vanillin 

Downstream Products

• 23693-38-1 β-(3-methoxy-4,5-methylenedioxy)phenylethylamine 
• 36017-64-8 (±)-β-N-demethyl noscapine 
• 128-62-1 (±)-β-noscapine 
• 408511-36-4 N-[2-(7-methoxy-benzo[1,3]dioxol-5-yl)-ethyl]-N-(3-methoxy-benzyl)-formamide 
• 408511-25-1 [2-(7-methoxy-benzo[1,3]dioxol-5-yl)-ethyl]-(3-methoxy-benzyl)-methyl-amine 
• 855395-40-3 [2-(7-methoxy-benzo[1,3]dioxol-5-yl)-ethyl]-(3-methoxy-benzyl)-amine 

Relevant academic research and scientific papers

An Acid-Catalyzed Epoxide Ring-Opening/Transesterification Cascade Cyclization to Diastereoselective Syntheses of (±)-β-Noscapine and (±)-β-Hydrastine

An acid-catalyzed stereoselective epoxide ring-opening/intramolecular transesterification cascade cyclization reaction and N-Boc deprotection was found to be a successful strategy to construct the phthalide tetrahydroisoquinoline skeleton in one pot. Based on this strategy, the unified and highly diastereoselective routes for the total syntheses of (±)-β-Noscapine and (±)-β-Hydrastine were exploited.

E-Combretastatin and E-resveratrol structural modifications: Antimicrobial and cancer cell growth inhibitory β-E-nitrostyrenes

As part of a broad-based SAR investigation of E-resveratrol (strong sirtuin activator and antineoplastic) and the anticancer vascular-targeting combretastatin-type stilbenes, a series of twenty-three β-E-nitrostyrenes was synthesized in order to evaluate potential antineoplastic, antitubulin, and antimicrobial activities. The β-E-nitrostyrenes evaluated ranged from monosubstituted phenols to trimethoxy and 3-methoxy-4,5-methylenedioxy derivatives. Two of the β-nitrostyrenes were synthesized as water-soluble sodium phosphate derivatives (4t, 4v). All except four (4r, 4s, 4t, 4u) of the series significantly inhibited a minipanel of human cancer cell lines. All but eight led to an IC50 of 10 μM for inhibition of tubulin polymerization, and all except three (4l, 4t, 4v) displayed antimicrobial activity.

Development of a catalytic enantioselective conjugate addition of 1,3-dicarbonyl compounds to nitroalkenes for the synthesis of endothelin-A antagonist ABT-546. Scope, mechanism, and further application to the synthesis of the antidepressant rolipram

The enantioselective synthesis of endothelin-A antagonist ABT-546 has been accomplished via the discovery and development of a highly selective catalytic asymmetric conjugate addition of ketoesters to nitroolefins. Employing just 4 mol % bis(oxazoline)-Mg

Endothelin antagonists

A compound of the formula (I): or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.