158962-65-3Relevant academic research and scientific papers
Asymmetric Synthesis and Absolute Stereochemistry of Cholesterol Absorption Inhibitor, SCH 484661.
Burnett, Duane A.
, p. 7339 - 7342 (1994)
The first asymmetric synthesis of cholesterol absorption inhibitor, SCH 48461 is described.The compound was prepared from an asymmetric ester enolate-imine condensation using Oppolzer's chiral ester or the corresponding menthol ester as the stereocontroll
Quantitative Analyses of Biochemical Kinetic Resolution of Enantiomers. 2. Enzyme-Catalyzed Esterification in Water-Organic Solvent Biphasic Systems
Chen, Ching-Shih,Wu, Shih-Hsiung,Girdaukas, Gary,Sih, Charles J.
, p. 2812 - 2817 (2007/10/02)
New quantitative expressions, which relate the kinetic and thermodynamic parameters that govern the stereospecificity of enzyme-catalyzed resolution of enantiomers in biphasic aqueous-organic media, have been developed.The theoretical predictions have been verified experimentally, and the technical merit of this esterification methodology has been assessed in relation to the more conventional hydrolytic procedure.
