158980-66-6Relevant articles and documents
Divergent response of homologous ATP sites to stereospecific ligand fluorination for selectivity enhancement
Patel, Alpesh Ramanlal,Hardianto, Ari,Ranganathan, Shoba,Liu, Fei
, p. 1570 - 1574 (2017/02/23)
Acquiring a divergent response from homologous protein domains is essential for selective ligand-protein interactions. Stereospecific fluorination of (?)-balanol, an ATP mimic, uncovers a new source of selectivity from integrated chemical and conformational perturbation that differentiates homologous sites by the level of congruency in their response to local and remote fluorine effects.
Total Synthesis of (-)-Balanol
Lampe, John W.,Hughes, Philip F.,Biggers, Christopher K.,Smith, Shelley H.,Hu, Hong
, p. 5147 - 5148 (2007/10/02)
(-)-Balanol, a fungal metabolite with potent protein kinase C inhibitory properties, has been prepared in a total synthesis which makes use of an anionic homo-Fries rearrangement approach to the benzophenone subunit and in which the azepane subunit is obt