158985-00-3 Usage
Uses
L-745,870 is a drug which acts as a dopamine receptor antagonist selective for the D4 subtype, and has antipsychotic effects in animal models, though it was not effective in human trials.
Biological Activity
A highly potent and selective D 4 dopamine receptor antagonist; L-745,870 has K i values of 0.51, 2300 and 960 nM for D 4 , D 3 and D 2 subtypes respectively and > 1000-fold selectivity over 5-HT 2 , D 1 and D 5 receptors.
Check Digit Verification of cas no
The CAS Registry Mumber 158985-00-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,8,9,8 and 5 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 158985-00:
(8*1)+(7*5)+(6*8)+(5*9)+(4*8)+(3*5)+(2*0)+(1*0)=183
183 % 10 = 3
So 158985-00-3 is a valid CAS Registry Number.
InChI:InChI=1/C18H19ClN4.3ClH/c19-15-3-5-16(6-4-15)23-10-8-22(9-11-23)13-14-12-21-18-17(14)2-1-7-20-18;;;/h1-7,12H,8-11,13H2,(H,20,21);3*1H
158985-00-3Relevant articles and documents
3-[[4-(4-Chlorophenyl)piperazin-1-yl]-methyl]-1H-pyrrolo[2,3-b]pyridine: An antagonist with high affinity and selectivity for the human dopamine D4 receptor
Kulagowski, Janusz J.,Broughton, Howard B.,Curtis, Neil R.,Mawer, Ian M.,Ridgill, Mark P.,Baker, Raymond,Emms, Frances,Freedman, Stephen B.,Marwood, Rosemarie,Patel, Shil,Patel, Smita,Ragan, C. Ian,Leeson, Paul D.
, p. 1941 - 1942 (1996)
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Pyrrolo-pyridine derivatives
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, (2008/06/13)
A class of pyrrolo[2,3-b]pyridine derivatives, substituted at the 3-position by a substituted piperazinylmethyl moiety, are antagonists of dopamine receptor subtypes within the brain, having a selective affinity for the dopamine D 4 receptor subtype over other dopamine receptor subtypes, and are accordingly of benefit in the treatment and/or prevention of psychotic disorders such as schizophrenia while manifesting fewer side-effects than those associated with classical neuroleptic drugs.