159000-54-1Relevant articles and documents
Selenium-containing photosensitizer as well as preparation method and application thereof
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Paragraph 0037; 0039; 0040; 0041, (2018/07/07)
The invention discloses a selenium-containing photosensitizer as well as a preparation method and application thereof. A novel selenium-containing photosensitizer with an anti-tumor angiogenesis effect is synthesized for a first time. The selenium-containing photosensitizer can be applied to treatment on skin scale cancer and is remarkable in effect, the dosage of the selenium-containing photosensitizer is far lower than that of 5-ALA in the market, in addition is free of antibiotics, free of drug resistance and small in side effect, and is safe and non-toxic and economic and practical; in addition, because of the limited light penetration function and other factors, a tumor treatment effect can be achieved even for tumor tissue without light dynamic response through tumor angiogenesis inhibition.
An enantioselective route to pyrrolidines: Removal of the chiral template from homochiral pyrroloimidazoles
Jones, Raymond C.F.,Howard, Kevin J.,Snaith, John S.,Blake, Alexander J.,Li, Wang-Shei,Steel, Peter J.
experimental part, p. 8925 - 8936 (2011/12/02)
Two-step reductive removal of the chiral template from optically active pyrroloimidazoles, available from 1,3-dipolar cycloaddition of homochiral 4,5-dihydroimidazolium ylides, gives optically active substituted pyrrolidines. Selective manipulation of the substituents affords, e.g., naturally occurring and other optically active proline derivatives, and optically active pyrrolizidines and indolizidines.
Asymmetric synthesis of 2,4-disubstituted pyrrolidines
Wang, Qian,Sasaki, N. Andre,Potier, Pierre
, p. 5755 - 5758 (2007/10/03)
A new strategy for asymmetric synthesis of 2,4-disubstituted pyrrolidines is described, starting from readily available chiral building blocks 1 and (2R)-2,3-O-isopropylideneglycealdehyde (6).