15901-11-8Relevant articles and documents
Synthesis of phosphinic acid analogues of glycyl-glycine and crystal structure of n-glycyl-aminomethyl-(phenylphosphinic) acid
Lukas, Michal,Vojtisek, Pavel,Hermann, Petr,Rohovec, Jan,Lukes, Ivan
, p. 79 - 88 (2002)
Phosphinic acid analogues of Gly-Gly, NH2CH2CONHCH2-P(R)O2H (R=Me, Ph, t-Bu), were synthesised by the active ester method from free aminomethylphosphinic acids purified on cation exchange resins. The crystal and
Process for the preparation of aminomethanephosphonic acid and aminomethylphosphinic acids
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, (2008/06/13)
Aminomethanephosphonic acid and aminomethylphosphinic acids are interesting as biologically active compounds or as intermediates for the preparation of biologically active compounds. According to the invention, such compounds of the formula I STR1 in which R1 is OH, C1 -C4 -alkyl or phenyl, can be prepared in a technically simple manner by reacting compounds of the formula II STR2 in which R2 is H, C1 -C6 -alkyl, benzyl, phenyl, optionally substituted by C1 -C4 -alkyl, -alkoxy and/or halogen, and R1 is as defined above, with water, at 80° to 300° C.
Peptides containing the novel Methylphosphinamide Transition-State Isostere
Moree, Wilna J.,Marel, Gijs A. van der,Boom, Jacques H. van,Liskamp, Rob M. J.
, p. 11055 - 11064 (2007/10/02)
A convenient route towards the synthesis of peptides containing the methylphosphinamide moiety as a novel transition-state isostere of the amide bond hydrolysis is described.The key step being the coupling of a methylphosphinic chloride with an amino acid
