1590338-44-5

Basic information

• Product Name: 4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione
• Synonyms: 4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione
• CAS NO: 1590338-44-5
• Molecular Weight: 356.663
• Mol File: 1590338-44-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione(1590338-44-5)
• EPA Substance Registry System: 4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione(1590338-44-5)

Safety Data

• Hazardous Substances Data: 1590338-44-5(Hazardous Substances Data)

Upstream product

• 536-40-3 4-chlorobenzoic acid hydrazide 
• 6590-96-1 2, 4-dichlorophenyl isothiocyanate 
• 891643-33-7 1-(4-chlorobenzoyl)-4-(2,4-dichlorophenyl)thiosemicarbazide 

Relevant articles and documents

Studies on the anticonvulsant activity and influence on GABA-ergic neurotransmission of 1,2,4-triazole-3-thione-based compounds

The anticonvulsant activity of several 1,2,4-triazole-3-thione derivatives on mouse maximal electroshock-induced seizures was tested in this study. Characteristic features of all active compounds were rapid onset of action and long lasting effect. Structure-activity observations showed that the probability of obtaining compounds exerting anticonvulsant activity was much higher when at least one of the phenyl rings attached to 1,2,4-triazole nucleus had a substituent at the para position. The obtained results, moreover, permit us to conclude that despite the structural similarity of loreclezole (second-generation anticonvulsant drug) and the titled compounds, their anticonvulsant activity is achieved via completely different molecular mechanisms.