1590340-33-2

Upstream product

• 120-72-9 indole 
• 82456-37-9 1-phenylpent-4-en-2-one 

Relevant academic research and scientific papers

Synthesis of 3-substituted indole by AlCl3-promoted reaction of β,γ-unsaturated ketone with indole

A one-pot Lewis acid-promoted reaction condition of β,γ- unsaturated ketone with indole was developed for the synthesis of 3-substituted indoles with moderate to good yields. A Lewis acid such as AlCl3 was shown to be a promising promoter for in situ isomerization of β,γ-unsaturated ketone to its corresponding α,β- unsaturated ketone, then undergoing Friedel-Crafts Michael addition reaction with indole to afford 3-substituted indole.