15904-98-0

Basic information

• Product Name: L-Glutamic acid, 4-hydroxy-4-methyl-, (4S)-
• CAS NO: 15904-98-0
• Molecular Formula: C6H11NO5
• Molecular Weight: 177.157
• Mol File: 15904-98-0.mol

Chemical Properties

• CAS DataBase Reference: L-Glutamic acid, 4-hydroxy-4-methyl-, (4S)-(CAS DataBase Reference)
• NIST Chemistry Reference: L-Glutamic acid, 4-hydroxy-4-methyl-, (4S)-(15904-98-0)
• EPA Substance Registry System: L-Glutamic acid, 4-hydroxy-4-methyl-, (4S)-(15904-98-0)

Safety Data

• Hazardous Substances Data: 15904-98-0(Hazardous Substances Data)

Upstream product

• 19071-44-4 4-hydroxy-4-methyl-2-ketoglutaric acid 

Relevant articles and documents

Chemoenzymatic synthesis of glutamic acid analogues: Substrate specificity and synthetic applications of branched chain aminotransferase from Escherichia coli

(Chemical Equation Presented) A new route to α-keto acids is described, based on the ozonolysis of enol acetates obtained from α-substituted β-keto esters. Escherichia coli branched chain aminotransferase (BCAT) activity toward a variety of substituted 2-oxoglutaric acids was demonstrated analytically. BCAT was shown to have a broad substrate spectrum, complementary to that of aspartate aminotransferase, and to offer access to a variety of glutamic acid analogues. The usefulness of BCAT was demonstrated through the synthesis of several 3- and 4-substituted derivatives.

Synthesis of 4,4-Disubstituted L-Glutamic Acids by Enzymatic Transamination

The syntheses of optically pure 4,4-dimethyl-L-glutamic acid as well as (2S,4R)- and (2S,4S)-4-hydroxy-4-methylglutamic acids have been achieved by transamination of the corresponding 2-oxo-4,4-dimethyl- and rac-2-oxo-4-hydroxy-4-methylglutaric acids using glutamic oxalacetic transaminase (GOT).