1590442-40-2Relevant academic research and scientific papers
PdII-catalyzed mild C-H ortho arylation and intramolecular amination oriented by a phosphinamide group
Guan, Jing,Wu, Guo-Jie,Han, Fu-She
supporting information, p. 3301 - 3305 (2014/04/03)
A novel protocol for the Pd-catalyzed ortho-arylation of aryl phosphinamide with boronic acid is reported. By using phosphinamide as a new directing group, the reaction proceeds efficiently under mild conditions at 40 °C. Mechanistic studies reveal that the reaction proceeds via a PdII to Pd0 cycle. The phosphinamide group is also shown to be an effective orienting group for direct C-H amination.
