1590450-18-2Relevant academic research and scientific papers
Neutral Alcohol Nucleophiles for the Substitution of α-Bromo Aryl Acetates and Applications to Asymmetric Synthesis of Morpholine Derivatives
Park, Wongi,Kim, Yongtae,Park, Yong Sun
supporting information, p. 2671 - 2674 (2019/04/13)
Highly stereoselective C–O bond formation in AgOTf-catalyzed substitution of configurationally labile α-bromo aryl acetates with neutral alcohol is developed. Also, application of this asymmetric synthetic methodology to the preparation of highly enantioenriched 2-aryl-substituted morpholine derivatives is presented.
N-benzoyl-L-threonine-isopropyl-ester-mediated crystallization-induced dynamic resolution of α-bromo arylacetates for the asymmetric synthesis of α-thio and α-oxy arylacetates
Park, Kon Ji,Kim, Yelim,Lee, Myung-Su,Park, Yong Sun
, p. 1645 - 1652 (2014/03/21)
N-Benzoyl-L-threonine-isopropyl-ester-mediated crystallization-induced dynamic resolution (CIDR) of configurationally labile α-bromo arylacetates has been investigated. The CIDR was successfully used for the asymmetric preparation of these compounds with
N-Benzoyl- L -Threonine-Isopropyl-Ester-Mediated Crystallization-Induced Dynamic Resolution of α-Bromo Arylacetates for the Asymmetric Synthesis of α-Thio and α-Oxy Arylacetates
Park, Kon Ji,Kim, Yelim,Lee, Myung-Su,Park, Yong Sun
, p. 1645 - 1652 (2015/10/05)
N-Benzoyl-L-threonine-isopropyl-ester-mediated crystallization-induced dynamic resolution (CIDR) of configurationally labile α-bromo arylacetates has been investigated. The CIDR was successfully used for the asymmetric preparation of these compounds with up to 98:2 dr, under solution and solvent-free conditions. Subsequent nucleophilic substitution reactions with sulfur and oxygen nulceophiles gave α-thio and α-oxy arylacetates with up to 98:2 dr. The method was further developed for the preparation of highly enantioenriched 2-phenylthio-2-arylethanols with up to 97:3 er, and 1,4-benzoxazin-3-ones with up to 94:6 er.
