159048-94-9Relevant academic research and scientific papers
One-pot synthesis ofN-substituted benzannulated triazolesviastable arene diazonium salts
Faggyas, Réka J.,McGrory, Rochelle,Sutherland, Andrew
supporting information, p. 6127 - 6140 (2021/07/21)
A mild and effective one-pot synthesis of 1,2,3-benzotriazin-4(3H)-ones and benzothiatriazine-1,1(2H)-dioxide analogues has been developed. The method involves the diazotisation and subsequent cyclisation of 2-aminobenzamides and 2-aminobenzenesulfonamidesviastable diazonium salts, prepared using a polymer-supported nitrite reagent andp-tosic acid. The transformation was compatible with a wide range of aryl functional groups and amide/sulfonamide-substituents and was used for the synthesis of pharmaceutically important targets. The synthetic utility of the one-pot diazotisaton-cyclisation process was further demonstrated with the preparation of an α-amino acid containing 1,2,3-benzotriazin-4(3H)-one.
Transition-Metal-Free Tandem Cyclization/ N-Arylation Reaction: A Method to Access Biaryl Sultam Derivatives via a Diradical Pathway
Thorat, Vijaykumar H.,Hsieh, Jen-Chieh,Cheng, Chien-Hong
supporting information, p. 6623 - 6627 (2020/09/02)
A novel procedure for the transition-metal-free tandem cyclization/N-arylation reaction sequence of an aryne with a 1,2,3,4-benzothiatriazine-1,1-dioxide is reported. This reaction goes through the intramolecular homolytic cyclization to generate an N-H b
Dibenzo[1,2,5]thiadiazepines are non-competitive GABAA receptor antagonists
Ramirez-Martinez, Juan F.,Gonzalez-Chavez, Rodolfo,Guerrero-Alba, Raquel,Reyes-Gutierrez, Paul E.,Martinez, Roberto,Miranda-Morales, Marcela,Espinosa-Luna, Rosa,Gonzalez-Chavez, Marco M.,Barajas-Lopez, Carlos
, p. 894 - 913 (2013/03/28)
A new process for obtaining dibenzo[c,f][1,2,5]thiadiazepines (DBTDs) and their effects on GABAA receptors of guinea pig myenteric neurons are described. Synthesis of DBTD derivatives began with two commercial aromatic compounds. An azide group was obtain
