159053-39-1Relevant articles and documents
Direct, Catalytic α-Alkylation of N-Heterocycles by Hydroaminoalkylation: Substrate Effects for Regiodivergent Product Formation
Daneshmand, Pargol,Dipucchio, Rebecca C.,Ezhova, Maria B.,Lenzen, Karst E.,Schafer, Laurel L.
supporting information, p. 11243 - 11250 (2021/08/03)
Saturated N-heterocycles are prevalent in pharmaceutical and agrochemical industries, yet remain challenging to catalytically alkylate. Most strategies for C-H activation of these challenging substrates use protected amines or high loadings of precious me
GROUP 5 METAL COMPLEXES FOR CATALYTIC AMINE FUNCTIONALIZATION
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Page/Page column 47-51, (2018/12/14)
This application pertains to group 5 metal complexes having the structure of Formula I; and their potential utility in catalyzing α-alkylation of secondary amine-containing moieties.
Development of an R-selective amine oxidase with broad substrate specificity and high enantioselectivity
Heath, Rachel S.,Pontini, Marta,Bechi, Beatrice,Turner, Nicholas J.
, p. 996 - 1002 (2014/05/06)
Amine oxidases are useful bio-catalysts for the synthesis of enantiomerically pure 1°, 2° and 3° chiral amines. Enzymes in this class (e.g., MAO-N from Aspergillus niger) reported previously have been shown to be highly S selective. Herein we report the development of an enantiocomplementary R-selective amine oxidase based on 6-hydroxy-D-nicotine oxidase (6-HDNO) with broadened substrate scope and high enantioselectivity. The engineered 6-HDNO enzyme has been applied to the preparative deracemisation of a range of racemic amines to yield S-configured products, for example, (S)-nicotine, in high ee. Nicotine rush: An R-selective amine oxidase based on 6-hydroxy-D-nicotine oxidase (6-HDNO) with broadened substrate scope and high enantioselectivity has been developed. The engineered 6-HDNO enzyme is applied to the preparative deracemization of a range of racemic amines to yield S-configured products, for example, (S)-nicotine, in high ee.